ArticleEvolution; international journal of organic evolution2017
Parasites and competitors suppress bacterial pathogen synergistically due to evolutionary trade-offs.
Article in Evolution; international journal of organic evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Bacteria-phage coevolution drives variation in bacterial wilt disease incidence via resistance-virulence trade-offs.Nature microbiology · 2026Article
- A Century-Old Solution for 21st Century Challenges: Current Applications with a Focus on Biocontrol, Environmental Impacts, and Regulatory Perspectives.Antibiotics (Basel, Switzerland) · 2026Review
- Wood Hemicellulose-Based Spray-Dried Microencapsulation of a Lytic Bacteriophage Preserves Phage Viability and Improves Control of the Bacterial Wilt Pathogen Ralstonia solanacearum.Microbial biotechnology · 2026Article
- Bacteria-phage (co)evolution is constrained in a synthetic community across multiple bacteria-phage pairs.Microbiology (Reading, England) · 2025Article
- Enhanced bacteriostatic effects of phage vB_C4 and cell wall-targeting antibiotic combinations against drug-resistantMicrobiology spectrum · 2025Article
- Harnessing Bacteriophages for Sustainable Crop Protection in the Face of Climate Change.Microbial biotechnology · 2025Review
- Phage biocontrol success of bacterial wilt depends on synergistic interactions with resident rhizosphere microbiota.Microbial biotechnology · 2024Article
- Protorhabditis nematodes and pathogen-antagonistic bacteria interactively promote plant health.Microbiome · 2024Article
- Phages enhance both phytopathogen density control and rhizosphere microbiome suppressiveness.mBio · 2024Article
- The role of rhizosphere phages in soil health.FEMS microbiology ecology · 2024Review
- Phage selection drives resistance-virulence trade-offs inEvolution letters · 2024Article
- Article
- Identifying and tracking mobile elements in evolving compost communities yields insights into the nanobiome.ISME communications · 2023Article
- Decolonizing drug-resistantMicrobiology (Reading, England) · 2023Article
- Bacterial volatile organic compounds attenuate pathogen virulence via evolutionary trade-offs.The ISME journal · 2023Article
- Rhizosphere phage communities drive soil suppressiveness to bacterial wilt disease.Microbiome · 2023Article
- Phage combination alleviates bacterial leaf blight of rice (Frontiers in plant science · 2023Article
- Article
- Indirect reduction of Ralstonia solanacearum via pathogen helper inhibition.The ISME journal · 2022Article
- Shotgun metagenomics evaluation of soil fertilization effect on the rhizosphere viral community of maize plants.Antonie van Leeuwenhoek · 2022Article
Corrections and comments
- Commented on by
Authors and funding
10 authors.
Funding
Abstract
Parasites and competitors are important for regulating pathogen densities and subsequent disease dynamics. It is, however, unclear to what extent this is driven by ecological and evolutionary processes. Here, we used experimental evolution to study the eco-evolutionary feedbacks among Ralstonia solanacearum bacterial pathogen, Ralstonia-specific phage parasite, and Bacillus amyloliquefaciens competitor bacterium in the laboratory and plant rhizosphere. We found that while the phage had a small effect on pathogen densities on its own, it considerably increased the R. solanacearum sensitivity to antibiotics produced by B. amyloliquefaciens. Instead of density effects, this synergy was due to phage-driven increase in phage resistance that led to trade-off with the resistance to B. amyloliquefaciens antibiotics. While no evidence was found for pathogen resistance evolution to B. amyloliquefaciens antibiotics, the fitness cost of adaptation (reduced growth) was highest when the pathogen had evolved in the presence of both parasite and competitor. Qualitatively similar patterns were found between laboratory and greenhouse experiments even though the evolution of phage resistance was considerably attenuated in the tomato rhizosphere. These results suggest that evolutionary trade-offs can impose strong constraints on disease dynamics and that combining phages and antibiotic-producing bacteria could be an efficient way to control agricultural pathogens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.