ArticleThe journal of nutrition, health & aging2016
Is the 25-Hydroxy-Vitamin D Serum Concentration a Good Marker of Frailty?
Article in The journal of nutrition, health & aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Low Vitamin D Levels and Frailty Status in Older Adults: A Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: a systematic review and dose-response meta-analysis.BMC geriatrics · 2018Pooled it
- Vitamin D deficiency and disease conditions relevant to: Orthopaedic translation.Journal of orthopaedic translation · 2026Review
- A Mendelian randomization study to examine the causal associations of circulating micronutrient levels with frailty risk.Frontiers in nutrition · 2024Article
- Association between vitamin D3 levels and frailty in the elderly: A large sample cross-sectional study.Frontiers in nutrition · 2022Article
- The role of vitamin D in the link between physical frailty and cognitive function: A mediation analysis in community-dwelling Chinese older adults.Frontiers in nutrition · 2022Article
- Pinpointing a Role for Vitamin D in Frailty: A Time for Animal Models?Advances in geriatric medicine and research · 2021Article
- Editorial: Vitamin D: Does the Emperor Have No Clothes?The journal of nutrition, health & aging · 2019Article
- Vitamin D Deficiency and Insufficiency Prevalence in the West of Ireland - A Retrospective Study.The journal of nutrition, health & aging · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe phenotype proposed by Fried and colleagues is a widely used operational definition of frailty defining such state of extreme vulnerability of older persons. Low serum 25-hydroxy-vitamin D (25(OH)D) has been suggested as biomarker of frailty in literature. STUDY
designCross-sectional.
objectivesTo explore the association of 25(OH)D concentrations with the frailty phenotype and its criteria.
methods321 subjects referred by their general practitioner to a geriatric frailty clinic were assessed between January 1, 2013 and September 23, 2013. Adjusted logistic regression models were performed between serum concentrations of 25(OH)D and the frailty phenotype (global score as well as its specific criteria). Receivers operating curves were established in order to explore the existence of a possible threshold of vitamin D levels highly predictive of frailty.
resultsTwo hundred forty-one (75%) participants had 25(OH)D levels lower than 22 ng/ml. No significant association was reported between 25(OH)D levels and frailty. Among the five criteria of frailty, 25(OH)D was only associated with sedentariness (odds ratio 0.97 [95% confidence interval 0.95-0.99]).
conclusionIn our sample, no association was found between 25(OH)D levels and phenotype of frailty or the different frailty criterion except for sedentariness.
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