ArticleScientific reports2016
Assessment of virulence potential of uncharacterized Enterococcus faecalis strains using pan genomic approach - Identification of pathogen-specific and habitat-specific genes.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Pan-genome analysis reveals the triangle mechanisms of antibiotic resistance, pathogenicity, and biofilm formation in Enterococcus faecalis.Molecular genetics and genomics : MGG · 2026Article
- Genomic diversity, antibiotic resistance, and virulence in South African Enterococcus faecalis and Enterococcus lactis isolates.World journal of microbiology & biotechnology · 2024Article
- Pan-Genome-Wide Association Study of Serotype 19A Pneumococci Identifies Disease-Associated Genes.Microbiology spectrum · 2023Article
- First Report of a Wastewater Treatment-Adapted Enterococcus faecalis ST21 Harboring vanA Gene in Brazil.Current microbiology · 2023Article
- Promoter DNA recognition by theFrontiers in molecular biosciences · 2023Article
- Characterizing Antimicrobial Resistance in Clinically Relevant Bacteria Isolated at the Human/Animal/Environment Interface Using Whole-Genome Sequencing in Austria.International journal of molecular sciences · 2022Article
- Comparative Genomics Reveals Genetic Diversity and Metabolic Potentials of the GenusMicrobiology spectrum · 2022Article
- Evidence of homologous recombination as a driver of diversity inMicrobial genomics · 2020Article
- Comparative genomics of globalMicrobial genomics · 2020Article
- Comparison of Antimicrobial Resistance and Pan-Genome of Clinical and Non-ClinicalFoods (Basel, Switzerland) · 2020Article
- Comparative genome analysis reveals key genetic factors associated with probiotic property in Enterococcus faecium strains.BMC genomics · 2018Article
- PanGFR-HM: A Dynamic Web Resource for Pan-Genomic and Functional Profiling of Human Microbiome With Comparative Features.Frontiers in microbiology · 2018Article
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4 authors.
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Abstract
Enterococcus faecalis, a leading nosocomial pathogen and yet a prominent member of gut microbiome, lacks clear demarcation between pathogenic and non-pathogenic strains at genome level. Here we present the comparative genome analysis of 36 E. faecalis strains with different pathogenic features and from different body-habitats. This study begins by addressing the genome dynamics, which shows that the pan-genome of E. faecalis is still open, though the core genome is nearly saturated. We identified eight uncharacterized strains as potential pathogens on the basis of their co-segregation with reported pathogens in gene presence-absence matrix and Pathogenicity Island (PAI) distribution. A ~7.4 kb genomic-cassette, which is itself a part of PAI, is found to exist in all reported and potential pathogens, but not in commensals and other uncharacterized strains. This region encodes four genes and among them, products of two hypothetical genes are predicted to be intrinsically disordered that may serve as novel targets for therapeutic measures. Exclusive existence of 215, 129, 4 and 1 genes in the blood, gastrointestinal tract, urogenital tract, oral cavity and lymph node derived E. faecalis genomes respectively suggests possible employment of distinct habitat-specific genetic strategies in the adaptation of E. faecalis in human host.
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