Evidence map›Paper›PMID 27924950›Full record

ArticleScientific reports2016

Molecular gated nanoporous anodic alumina for the detection of cocaine.

Àngela Ribes, Elisabet Xifré-Pérez, Elena Aznar, Félix Sancenón, Teresa Pardo, Lluís F Marsal, Ramόn Martínez-Máñez

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Àngela RibesInstituto Interuniversitario de Investigaciόn de Reconocimiento Molecular y Desarrollo Tecnolόgico (IDM). Universitat Politècnica de València, Universitat de València, Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain.
Elisabet Xifré-PérezDepartamento de Ingeniería Electrónica, Eléctrica y Automática, Universidad Rovira i Virgili, Avda. Països Catalans 26, 43007, Tarragona, Spain.
Elena AznarInstituto Interuniversitario de Investigaciόn de Reconocimiento Molecular y Desarrollo Tecnolόgico (IDM). Universitat Politècnica de València, Universitat de València, Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain.
Félix SancenónInstituto Interuniversitario de Investigaciόn de Reconocimiento Molecular y Desarrollo Tecnolόgico (IDM). Universitat Politècnica de València, Universitat de València, Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain.
Teresa PardoInstituto Interuniversitario de Investigaciόn de Reconocimiento Molecular y Desarrollo Tecnolόgico (IDM). Universitat Politècnica de València, Universitat de València, Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain.
Lluís F MarsalDepartamento de Ingeniería Electrónica, Eléctrica y Automática, Universidad Rovira i Virgili, Avda. Països Catalans 26, 43007, Tarragona, Spain.
Ramόn Martínez-MáñezInstituto Interuniversitario de Investigaciόn de Reconocimiento Molecular y Desarrollo Tecnolόgico (IDM). Universitat Politècnica de València, Universitat de València, Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, 46022, Valencia, Spain.
Universitat de València · ESUniversidad Rovira i Virgili · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present herein the use of nanoporous anodic alumina (NAA) as a suitable support to implement "molecular gates" for sensing applications. In our design, a NAA support is loaded with a fluorescent reporter (rhodamine B) and functionalized with a short single-stranded DNA. Then pores are blocked by the subsequent hybridisation of a specific cocaine aptamer. The response of the gated material was studied in aqueous solution. In a typical experiment, the support was immersed in hybridisation buffer solution in the absence or presence of cocaine. At certain times, the release of rhodamine B from pore voids was measured by fluorescence spectroscopy. The capped NAA support showed poor cargo delivery, but presence of cocaine in the solution selectively induced rhodamine B release. By this simple procedure a limit of detection as low as 5 × 10

Indexed as

Biosensing TechniquesElectrodesNanoporesAluminum OxideCocaineReproducibility of ResultsSensitivity and SpecificityAluminum OxideCocaine

Identifiers

PMID27924950
PMCPMC5141502
OpenAlexW2560228571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.