ArticleNature communications2016
Constraints and spandrels of interareal connectomes.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed.
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- Transcriptomic divergence of network hubs in the prenatal human brain.Communications biology · 2025Article
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- Mindfulness Meditation and Network Neuroscience: Review, Synthesis, and Future Directions.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Review
- Premature birth changes wiring constraints in neonatal structural brain networks.Nature communications · 2025Article
- A simulated annealing algorithm for randomizing weighted networks.Nature computational science · 2025Article
- Constructing representative group networks from tractography: lessons from a dynamical approach.Frontiers in network physiology · 2024Article
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- Unbiased and efficient sampling of timeseries reveals redundancy of brain network and gradient structure.NeuroImage · 2023Article
- Time-resolved correlation of distributed brain activity tracks E-I balance and accounts for diverse scale-free phenomena.Cell reports · 2023Article
- Brain connectivity meets reservoir computing.PLoS computational biology · 2022Article
- Null models in network neuroscience.Nature reviews. Neuroscience · 2022Review
- A guided multiverse study of neuroimaging analyses.Nature communications · 2022Article
- Edges in brain networks: Contributions to models of structure and function.Network neuroscience (Cambridge, Mass.) · 2022Review
- A generative network model of neurodevelopmental diversity in structural brain organization.Nature communications · 2021Observational
- Genetic influences on hub connectivity of the human connectome.Nature communications · 2021Observational
- Article
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Abstract
Interareal connectomes are whole-brain wiring diagrams of white-matter pathways. Recent studies have identified modules, hubs, module hierarchies and rich clubs as structural hallmarks of these wiring diagrams. An influential current theory postulates that connectome modules are adequately explained by evolutionary pressures for wiring economy, but that the other hallmarks are not explained by such pressures and are therefore less trivial. Here, we use constraint network models to test these postulates in current gold-standard vertebrate and invertebrate interareal-connectome reconstructions. We show that empirical wiring-cost constraints inadequately explain connectome module organization, and that simultaneous module and hub constraints induce the structural byproducts of hierarchies and rich clubs. These byproducts, known as spandrels in evolutionary biology, include the structural substrate of the default-mode network. Our results imply that currently standard connectome characterizations are based on circular analyses or double dipping, and we emphasize an integrative approach to future connectome analyses for avoiding such pitfalls.
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