Evidence map›Paper›PMID 27924840›Full record

ArticleScientific reports2016

Atmospheric Pressure Non-Equilibrium Plasma as a Green Tool to Crosslink Gelatin Nanofibers.

Anna Liguori, Adriana Bigi, Vittorio Colombo, Maria Letizia Focarete, Matteo Gherardi, Chiara Gualandi, Maria Chiara Oleari, Silvia Panzavolta

Abstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. The Use of Collagen-Based Materials in Bone Tissue Engineering.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Cross-Linking Agents for Electrospinning-Based Bone Tissue Engineering.International journal of molecular sciences · 2022
    Review
  12. [Effect of a novel radio-frequency atmospheric-pressure glow discharge plasma jet treatment on crosslinking of dentin collagen].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2022
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna LiguoriAdvanced Mechanics and Materials, Interdepartmental Center for Industrial Research (AMM-ICIR), Alma Mater Studiorum-University of Bologna, Via Saragozza 8, 40123 Bologna, Italy.
Adriana BigiDepartment of Chemistry "G. Ciamician", via Selmi 2, 40126 University of Bologna, Italy.
Vittorio ColomboAdvanced Mechanics and Materials, Interdepartmental Center for Industrial Research (AMM-ICIR), Alma Mater Studiorum-University of Bologna, Via Saragozza 8, 40123 Bologna, Italy.
Maria Letizia FocareteDepartment of Chemistry "G. Ciamician", via Selmi 2, 40126 University of Bologna, Italy.
Matteo GherardiAdvanced Mechanics and Materials, Interdepartmental Center for Industrial Research (AMM-ICIR), Alma Mater Studiorum-University of Bologna, Via Saragozza 8, 40123 Bologna, Italy.
Chiara GualandiDepartment of Chemistry "G. Ciamician", via Selmi 2, 40126 University of Bologna, Italy.
Maria Chiara OleariDepartment of Chemistry "G. Ciamician", via Selmi 2, 40126 University of Bologna, Italy.
Silvia PanzavoltaDepartment of Chemistry "G. Ciamician", via Selmi 2, 40126 University of Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrospun gelatin nanofibers attract great interest as a natural biomaterial for cartilage and tendon repair despite their high solubility in aqueous solution, which makes them also difficult to crosslink by means of chemical agents. In this work, we explore the efficiency of non-equilibrium atmospheric pressure plasma in stabilizing gelatin nanofibers. We demonstrate that plasma represents an innovative, easy and environmentally friendly approach to successfully crosslink gelatin electrospun mats directly in the solid state. Plasma treated gelatin mats display increased structural stability and excellent retention of fibrous morphology after immersion in aqueous solution. This method can be successfully applied to induce crosslinking both in pure gelatin and genipin-containing gelatin electrospun nanofibers, the latter requiring an even shorter plasma exposure time. A complete characterization of the crosslinked nanofibres, including mechanical properties, morphological observations, stability in physiological solution and structural modifications, has been carried out in order to get insights on the occurring reactions triggered by plasma.

Identifiers

PMID27924840
PMCPMC5141472

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.