ArticleScientific reports2016
Endogenous testosterone is associated with lower amygdala reactivity to angry faces and reduced aggressive behavior in healthy young women.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Neural correlates of aggression in personality disorders from the perspective of DSM-5 maladaptive traits: a systematic review.Translational psychiatry · 2023Pooled it
- The influence of the COMT Val158Met polymorphism on prefrontal TDCS effects on aggression.Scientific reports · 2024Trial
- Oxytocin effects on amygdala reactivity to angry faces in males and females with antisocial personality disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Neuropsychobiological transdiagnostic risk mechanisms for aggression in mental disorders across the life span.BMC psychiatry · 2026Article
- Lean muscle mass, not aggression, mediates a link between dominance rank and testosterone in wild male chimpanzees.Animal behaviour · 2023Article
- Neurobiology of Aggression-Review of Recent Findings and Relationship with Alcohol and Trauma.Biology · 2023Review
- State Anxiety and Procrastination: The Moderating Role of Neuroendocrine Factors.Behavioral sciences (Basel, Switzerland) · 2023Article
- Dissociation of behavioral and neural responses to provocation during reactive aggression in healthy adults with high versus low externalization.Cognitive, affective & behavioral neuroscience · 2022Article
- Inhibition of noncaspase proteases, calpain and proteasome, via ALLN and Bortezomib contributes to cell death through low degradation of pro-/anti-apoptotic proteins and apoptosis induction.Medical oncology (Northwood, London, England) · 2022Article
- Consequences of prefrontal tDCS on inhibitory control and reactive aggression.Social cognitive and affective neuroscience · 2022Article
- Structural and functional brain networks of individual differences in trait anger and anger control: An unsupervised machine learning study.The European journal of neuroscience · 2022Article
- Low competitive status elicits aggression in healthy young men: behavioural and neural evidence.Social cognitive and affective neuroscience · 2021Article
- Pubertal Testosterone and Brain Response to Faces in Young Adulthood: An Interplay between Organizational and Activational Effects in Young Men.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Understanding Brain Mechanisms of Reactive Aggression.Current psychiatry reports · 2020Review
- The personality dispositions and resting-state neural correlates associated with aggressive children.Social cognitive and affective neuroscience · 2020Article
- Positive Affect Moderates the Relationship Between Salivary Testosterone and a Health Behavior Composite in University Females.International journal of behavioral medicine · 2020Article
- Nervous and Endocrine System Dysfunction in Posttraumatic Stress Disorder: An Overview and Consideration of Sex as a Biological Variable.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Review
- Aggression in Women: Behavior, Brain and Hormones.Frontiers in behavioral neuroscience · 2018Review
- Testosterone promotes either dominance or submissiveness in the Ultimatum Game depending on players' social rank.Scientific reports · 2017Article
- Neural Correlates of Aggressive Behavior in Real Time: a Review of fMRI Studies of Laboratory Reactive Aggression.Current behavioral neuroscience reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Testosterone and cortisol have been proposed to influence aggressive behavior by altering the neural processing of facial threat signals. However, this has not been investigated in direct social interactions. Here, we explored the joint impact of testosterone, cortisol, and brain reactivity to anger expressions on women's reactive aggression in the Social Threat Aggression Paradigm (STAP). The STAP is a competitive reaction time task in which the purported opponent displays either an angry or a neutral facial expression at the beginning of each trial and delivers increasingly loud sound blasts to the participants, successfully provoking them. Strikingly, salivary testosterone at scan-time was negatively related to both aggression and basolateral amygdala (BLA) reactivity to angry faces, whereas cortisol had no effect. When the opponent looked angry, BLA-orbitofrontal coupling was reduced, and BLA reactivity was positively related to aggression. The latter relationship was fully mediated by bilateral superior temporal gyrus (STG) activation. Our results thus support previous neurobiological models of aggression, and extend them by demonstrating that fast amygdala responses to threat modulate STG activity in order to favor aggressive retaliation. Furthermore, our study agrees with recent evidence underscoring a fear-reducing and strategically prosocial effect of testosterone on human social behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.