ArticleEmerging microbes & infections2016
Insights into the evolution of pathogenicity of Escherichia coli from genomic analysis of intestinal E. coli of Marmota himalayana in Qinghai-Tibet plateau of China.
Article in Emerging microbes & infections, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed.
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- Chicken Production and Human ClinicalApplied and environmental microbiology · 2023Article
- Escherichia Coli: What Is and Which Are?Molecular biology and evolution · 2023Article
- Genomics and pathotypes of the many faces of Escherichia coli.FEMS microbiology reviews · 2022Article
- The microbial ecology of Escherichia coli in the vertebrate gut.FEMS microbiology reviews · 2022Review
- Escherichia marmotae-a Human Pathogen Easily Misidentified as Escherichia coli.Microbiology spectrum · 2022Article
- Prevalence and Diversity of Antibiotic ResistantFrontiers in public health · 2022Article
- Remarkable genomic diversity amongPeerJ · 2022Article
- Antimicrobial resistance surveillance ofFrontiers in microbiology · 2022Article
- Defensive hypervariable regions confer superinfection exclusion in microviruses.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The population genetics of pathogenic Escherichia coli.Nature reviews. Microbiology · 2021Review
- Phylogenetic background and habitat drive the genetic diversification of Escherichia coli.PLoS genetics · 2020Article
- UniqueInternational journal of molecular sciences · 2020Article
- Origin and Evolution of Hybrid Shiga Toxin-Producing and Uropathogenic Escherichia coli Strains of Sequence Type 141.Journal of clinical microbiology · 2019Article
- Stratified reconstruction of ancestral Escherichia coli diversification.BMC genomics · 2019Article
- Genomic and molecular characterisation of Escherichia marmotae from wild rodents in Qinghai-Tibet plateau as a potential pathogen.Scientific reports · 2019Article
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17 authors.
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Abstract
Escherichia coli is both of a widespread harmless gut commensal and a versatile pathogen of humans. Domestic animals are a well-known reservoir for pathogenic E. coli. However, studies of E. coli populations from wild animals that have been separated from human activities had been very limited. Here we obtained 580 isolates from intestinal contents of 116 wild Marmot Marmota himalayana from Qinghai-Tibet plateau, China, with five isolates per animal. We selected 125 (hereinafter referred to as strains) from the 580 isolates for genome sequencing, based on unique pulse field gel electrophoresis patterns and at least one isolate per animal. Whole genome sequence analysis revealed that all 125 strains carried at least one and the majority (79.2%) carried multiple virulence genes based on the analysis of 22 selected virulence genes. In particular, the majority of the strains carried virulence genes from different pathovars as potential 'hybrid pathogens'. The alleles of eight virulence genes from the Marmot E. coli were found to have diverged earlier than all known alleles from human and other animal E. coli. Phylogenetic analysis of the 125 Marmot E. coli genomes and 355 genomes selected from 1622 human and other E. coli strains identified two new phylogroups, G and H, both of which diverged earlier than the other phylogroups. Eight of the 12 well-known pathogenic E. coli lineages were found to share a most recent common ancestor with one or more Marmot E. coli strains. Our results suggested that the intestinal E. coli of the Marmots contained a diverse virulence gene pool and is potentially pathogenic to humans. These findings provided a new understanding of the evolutionary origin of pathogenic E. coli.
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