Evidence map›Paper›PMID 27924634›Full record

ReviewBiomarkers in medicine2016

The promise of circulating tumor cells for precision cancer therapy.

William L Hwang, Katie L Hwang, David T Miyamoto

Abstract readReview
In one paragraph

Review in Biomarkers in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Single-Cell Analysis of BRAFMethods in molecular biology (Clifton, N.J.) · 2021
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

William L HwangDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
Katie L HwangMassachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
David T MiyamotoDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA.
Massachusetts General Hospital · US

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
NIGMS NIH HHS T32 GM007753
6 · The paper itself

Abstract

The rapidly growing array of therapeutic options in cancer requires informative biomarkers to guide the rational selection and precision application of appropriate therapies. Circulating biomarkers such as circulating tumor cells have immense potential as noninvasive, serial 'liquid biopsies' that may be more representative of the complete spectrum of a patient's individual malignancy than spatially and temporally restricted tumor biopsies. In this review, we discuss the current state-of-the-art in the isolation and molecular characterization of circulating tumor cells as well as their utility in a wide range of clinical applications such as prognostics, treatment monitoring and identification of novel therapeutic targets and resistance mechanisms to enable real-time adjustments in the clinical management of cancer.

Indexed as

Biomarkers, TumorEpithelial-Mesenchymal TransitionHumansNeoplasm MetastasisNeoplasmsNeoplastic Cells, CirculatingPrognosisProstate-Specific AntigenTNF-Related Apoptosis-Inducing LigandBiomarkers, TumorProstate-Specific AntigenTNF-Related Apoptosis-Inducing Ligandcancercirculating tumor cells (CTCs)precision therapypredictive markerprognostic marker

Identifiers

PMID27924634
PMCPMC5827810
OpenAlexW2560575204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.