ArticleMolecular neurobiology2017
Cognitive Functioning in Temporal Lobe Epilepsy: A BOLD-fMRI Study.
Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- A meta-analysis on neural changes of cognitive training for mental disorders in executive function tasks: increase or decrease brain activation?BMC psychiatry · 2022Pooled it
- The Neural Mechanism of Long-Term Motor Training Affecting Athletes' Decision-Making Function: An Activation Likelihood Estimation Meta-Analysis.Frontiers in human neuroscience · 2022Pooled it
- ASD-GANNet: A Generative Adversarial Network-Inspired Deep Learning Approach for the Classification of Autism Brain Disorder.Brain sciences · 2024Article
- Abnormalities of regional brain activity and executive function in patients with temporal lobe epilepsy: A cross-sectional and longitudinal resting-state functional MRI study.Neuroradiology · 2024Article
- Distinguishing Patients with MRI-Negative Temporal Lobe Epilepsy from Normal Controls Based on Individual Morphological Brain Network.Brain topography · 2023Article
- Hyperphosphorylated Tau in Mesial Temporal Lobe Epilepsy: a Neuropathological and Cognitive Study.Molecular neurobiology · 2023Article
- Cerebellar functional disruption and compensation in mesial temporal lobe epilepsy.Frontiers in neurology · 2023Article
- Amplitude synchronization of spontaneous activity of medial and lateral temporal gyri reveals altered thalamic connectivity in patients with temporal lobe epilepsy.Scientific reports · 2022Article
- Network phenotypes and their clinical significance in temporal lobe epilepsy using machine learning applications to morphological and functional graph theory metrics.Scientific reports · 2022Article
- A study of brain functional network and alertness changes in temporal lobe epilepsy with and without focal to bilateral tonic-clonic seizures.BMC neurology · 2022Article
- Altered voxel-mirrored homotopic connectivity in right temporal lobe epilepsy as measured using resting-state fMRI and support vector machine analyses.Frontiers in psychiatry · 2022Article
- Abnormal Ventral Somatomotor Network Homogeneity in Patients With Temporal Lobe Epilepsy.Frontiers in psychiatry · 2022Article
- Altered interhemispheric functional homotopy and connectivity in temporal lobe epilepsy based on fMRI and multivariate pattern analysis.Neuroradiology · 2021Article
- Review
- Recent Advances in Neuroimaging of Epilepsy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Review
- Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China.Annals of global health · 2021Article
- Aberrant functional connectivity of the cingulate subregions in right-sided temporal lobe epilepsy.Experimental and therapeutic medicine · 2020Article
- Alterations Functional Connectivity in Temporal Lobe Epilepsy and Their Relationships With Cognitive Function: A Longitudinal Resting-State fMRI Study.Frontiers in neurology · 2020Article
- Functional and Structural Brain Alterations in Encephalitis With LGI1 Antibodies.Frontiers in neuroscience · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
We aimed to analyze the association between resting-state functional magnetic resonance imaging (re-fMRI) and cognitive function (including language, executive, and memory functions) in temporal lobe epilepsy (TLE) patients, which will help to explore the mechanism of brain function in patients. 15 TLE patients and 15 non-TLE patients were recruited. All subjects underwent neuropsychological testing and memory functional evaluation. Changes in verbal intelligence quotient (VIQ), performance intelligence quotient (PIQ), full intelligence quotient (FIQ), and memory quotient (MQ) were compared between two groups. Re-fMRI data were also collected from two groups to evaluate these changes. Each individual score of neuropsychological testing and memory functional evaluation were higher in control group, which was statistically different (all P < 0.01) while the VIQ, PIQ, FIQ, and MQ showed the same trend (all P < 0.01). The data showed the positive activation differences in brain regions between experimental and control group, namely right frontal lobe, the left middle temporal gyrus back, right superior temporal gyrus, left cerebellum, left angular gyrus, left wedge anterior lobe, and left central back; while the negatively activated brain regions were left prefrontal, right cerebellum, right corner back, and right anterior cingulate gyrus. During the language task, the activated brain regions of the TLE patients were right prefrontal lobe, the lateral temporal gyri, the left cerebellum, left cornu laterale gyrus, left precuneus, and the left postcentral gyrus, whereas the negatively activated brain areas were the left prefrontal cortex, the right cerebellum, right cornu laterale gyrus, and the right anterior cingulate gyrus. During the executive task, epilepsy patients showed activation difference in right prefrontal and right frontal lobe and right brain, left superior temporal gyrus, and right cerebellum anterior lobe compared with the control group; no negatively activated differences in brain areas. During the memory task, the difference lay in bilateral anterior cingulate gyrus and bilateral wedge anterior lobe while the negatively activated brain areas were the left inferior frontal gyrus and postcentral gyrus. The cognitive functioning is related to the functional connectivity within the cortex. There is a significant difference in the activation of brain areas during different tasks between the TLE patients and the non-TLE patients.
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