Evidence map›Paper›PMID 27924427›Full record

ArticleOral and maxillofacial surgery2017

Treatment of medication-related osteonecrosis of the jaws (MRONJ) with ultrasonic piezoelectric bone surgery. A case series of 20 treated sites.

Cornelio Blus, Giulio Giannelli, Serge Szmukler-Moncler, Germano Orru

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Article in Oral and maxillofacial surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

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0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cornelio BlusOdontology Biotechnology Laboratory, Department of Surgical Sciences, University of Cagliari, Cagliari, Italy. corblus@gmail.com.
Giulio GiannelliDepartment of Odontostomatology, Hospital Sacro Cuore di Gesù, Gallipoli, Lecce, Italy.
Serge Szmukler-MonclerOdontology Biotechnology Laboratory, Department of Surgical Sciences, University of Cagliari, Cagliari, Italy.
Germano OrruOdontology Biotechnology Laboratory, Department of Surgical Sciences, University of Cagliari, Cagliari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere is no consensus on how to successfully treat medication-related osteonecrosis of the jaws (MRONJ). We report here on the application of piezoelectric bone surgery to treat MRONJ in combination with antibiotherapy and on its possible benefit. MATERIEL AND

methodsA cohort of 18 consecutive patients has been treated for MRONJ; they involved 20 sites, 15 in the mandible, and five in the maxilla. Surgical removal of the necrotic areas and debridement was performed with a powerful piezoelectric surgery device (max 90 W) in combination with antibiotherapy.

resultsAll patients healed and obtained a complete soft tissue closure within 1 month. No recurrence of the symptoms was observed during the present follow-up (10-54 months).

conclusionWe hypothesize that healing of all treated sites might have resulted from the synergic effect of bone ablation, biofilm alteration, and antibiotic administration. Biofilm alteration might have permitted a better access of antibiotics to the involved germs. These encouraging results warrant further studies on the use of ultrasonic surgery to treat MRONJ patients in order to confirm or refute the hypothesized effect.

Indexed as

AgedAged, 80 and overAnti-Bacterial AgentsBisphosphonate-Associated Osteonecrosis of the JawCombined Modality TherapyFemaleFollow-Up StudiesHumansMaleMiddle AgedPiezosurgeryTreatment OutcomeUltrasonic Surgical ProceduresAnti-Bacterial AgentsBacterial biofilmBiphosphonate-related osteonecrosis of the jawMRONJPiezosurgerySurgical managementSurgical treatmentUltrasonic bone surgery

Identifiers

PMID27924427

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.