ArticleACS central science2016
A Compartmentalized Out-of-Equilibrium Enzymatic Reaction Network for Sustained Autonomous Movement.
Article in ACS central science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 151 citations in OpenAlex.
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- DNA affects the phenotype of fuel-dependent coacervate droplets.Nature communications · 2026Article
- Progress in enzyme-powered micro/nanomotors in diagnostics and therapeutics.Bioactive materials · 2025Review
- Designing polymersomes with surface-integrated nanoparticles through hierarchical phase separation.Nature communications · 2025Article
- Biomimetic Materials to Fabricate Artificial Cells.Chemical reviews · 2024Review
- Non-equilibrium self-assembly for living matter-like properties.Nature reviews. Chemistry · 2024Review
- Exploring Emergent Properties in Enzymatic Reaction Networks: Design and Control of Dynamic Functional Systems.Chemical reviews · 2024Review
- Dynamic metastable polymersomes enable continuous flow manufacturing.Nature communications · 2023Article
- Enzyme-powered micro- and nano-motors: key parameters for an application-oriented design.Chemical science · 2022Review
- Photo-Cross-Linking Polymersome Nanoreactors with Size-Selective Permeability.Macromolecules · 2022Article
- Twin-Engine Janus Supramolecular Nanomotors with Counterbalanced Motion.Journal of the American Chemical Society · 2022Article
- Chemically-powered swimming and diffusion in the microscopic world.Nature reviews. Chemistry · 2021Review
- pH Feedback Lifecycles Programmed by Enzymatic Logic Gates Using Common Foods as Fuels.Angewandte Chemie (International ed. in English) · 2021Article
- Enzyme-Loaded Nanoreactors Enable the Continuous Regeneration of Nicotinamide Adenine Dinucleotide in Artificial Metabolisms.Angewandte Chemie (International ed. in English) · 2021Article
- Autonomous Transient pH Flips Shaped by Layered Compartmentalization of Antagonistic Enzymatic Reactions.Angewandte Chemie (International ed. in English) · 2021Article
- Coupled Metabolic Cycles Allow Out-of-Equilibrium Autopoietic Vesicle Replication.Angewandte Chemie (International ed. in English) · 2020Article
- Engineering microrobots for targeted cancer therapies from a medical perspective.Nature communications · 2020Review
- Biofriendly micro/nanomotors operating on biocatalysis: from natural to biological environments.Biophysics reports · 2020Article
- Recent Advances in the Synthesis and Application of Polymer Compartments for Catalysis.Polymers · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Every living cell is a compartmentalized out-of-equilibrium system exquisitely able to convert chemical energy into function. In order to maintain homeostasis, the flux of metabolites is tightly controlled by regulatory enzymatic networks. A crucial prerequisite for the development of lifelike materials is the construction of synthetic systems with compartmentalized reaction networks that maintain out-of-equilibrium function. Here, we aim for autonomous movement as an example of the conversion of feedstock molecules into function. The flux of the conversion is regulated by a rationally designed enzymatic reaction network with multiple feedforward loops. By compartmentalizing the network into bowl-shaped nanocapsules the output of the network is harvested as kinetic energy. The entire system shows sustained and tunable microscopic motion resulting from the conversion of multiple external substrates. The successful compartmentalization of an out-of-equilibrium reaction network is a major first step in harnessing the design principles of life for construction of adaptive and internally regulated lifelike systems.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.