Evidence map›Paper›PMID 27924281›Full record

ArticleGenomics data2017

Causality analysis detects the regulatory role of maternal effect genes in the early

Zara Ghodsi, Xu Huang, Hossein Hassani

Abstract read
In one paragraph

Article in Genomics data, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zara GhodsiStatistical Research Centre, Bournemouth University, 89 Holdenhurst Road, Bournemouth BH8 8EB, UK; Translational Genetics Group, Bournemouth University, Fern Barrow, Poole BH125BB, UK.
Xu HuangStatistical Research Centre, Bournemouth University, 89 Holdenhurst Road, Bournemouth BH8 8EB, UK.
Hossein HassaniInstitute for International Energy Studies (IIES), Tehran 1967743 711, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In developmental studies, inferring regulatory interactions of segmentation genetic network play a vital role in unveiling the mechanism of pattern formation. As such, there exists an opportune demand for theoretical developments and new mathematical models which can result in a more accurate illustration of this genetic network. Accordingly, this paper seeks to extract the meaningful regulatory role of the maternal effect genes using a variety of causality detection techniques and to explore whether these methods can suggest a new analytical view to the gene regulatory networks. We evaluate the use of three different powerful and widely-used models representing time and frequency domain Granger causality and convergent cross mapping technique with the results being thoroughly evaluated for statistical significance. Our findings show that the regulatory role of maternal effect genes is detectable in different time classes and thereby the method is applicable to infer the possible regulatory interactions present among the other genes of this network.

Indexed as

BicoidCaudalConvergent Cross MappingDrosophila melanogasterSegmentationTime and frequency domain causality

Identifiers

PMID27924281
PMCPMC5129166

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.