Evidence map›Paper›PMID 27924162›Full record

ArticleTheranostics2016

A Pretargeted Approach for the Multimodal PET/NIRF Imaging of Colorectal Cancer.

Pierre Adumeau, Kathryn E Carnazza, Christian Brand, Sean D Carlin, Thomas Reiner, Brian J Agnew, Jason S Lewis, Brian M Zeglis

Abstract read
In one paragraph

Article in Theranostics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Radiolabeling andRSC chemical biology · 2023
    Article
  6. Article
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  8. Synthesis and radiolabeling of a polar [Journal of labelled compounds & radiopharmaceuticals · 2023
    Article
  9. Review
  10. Article
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  13. Development ofPharmaceuticals (Basel, Switzerland) · 2022
    Article
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  16. Article
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  18. HarnessingProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pierre AdumeauDepartment of Chemistry, Hunter College of the City University of New York, New York, NY, 10028.
Kathryn E CarnazzaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065.
Christian BrandDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065.
Sean D CarlinDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065.
Thomas ReinerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065;; Department of Radiology, Weill Cornell Medical College, New York, NY, 10065.
Brian J AgnewLicensing and Commercial Supply, Thermo Fisher Scientific, Eugene, OR, 97402.
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065;; Department of Radiology, Weill Cornell Medical College, New York, NY, 10065;; Program in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center, New York, NY, 10065.
Brian M ZeglisDepartment of Chemistry, Hunter College of the City University of New York, New York, NY, 10028;; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065;; Department of Radiology, Weill Cornell Medical College, New York, NY, 10065;; Ph.D. Program in Chemistry, the Graduate Center of the City University of New York, New York, NY, 10016.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Basic and Translational Research Center for Reducing Health DisparitiesG12MD007599 · NIMHD · HUNTER COLLEGE · PI ANGULO, JESUS A · 2012 to 2017
$14.6M
Memorial Sloan Kettering Small Animal Imaging ResearchR24CA083084 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI KOUTCHER, JASON ARTHUR · 1999 to 2006
$4.4M
The Clinical PET Imaging of Metastatic Breast Cancer with Site-Specifically Labeled 89Zr-TrastuzumabR01CA204167 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ULANER, GARY ALLAN · 2016 to 2020
$3.4M
Biomarkers for predicting response to Hsp90 therapyR01CA172546 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CHIOSIS, GABRIELA, DUNPHY, MARK P. · 2013 to 2017
$2.9M
Pretargeted Radioimmunotherapy Based on Bioorthogonal Click ChemistryR00CA178205 · NCI · HUNTER COLLEGE · PI ZEGLIS, BRIAN MATTHEW · 2015 to 2017
$747k
Pretargeted Radioimmunotherapy Based on Bioorthogonal Click ChemistryK99CA178205 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ZEGLIS, BRIAN MATTHEW · 2014 to 2014
$108k
NCI NIH HHS K99 CA178205NCI NIH HHS P30 CA008748NCI NIH HHS R00 CA178205NCI NIH HHS R01 CA172546NCI NIH HHS R01 CA204167NCI NIH HHS R24 CA083084NIMHD NIH HHS G12 MD007599
6 · The paper itself

Abstract

The complementary nature of positron emission tomography (PET) and near-infrared fluorescence (NIRF) imaging makes the development of strategies for the multimodal PET/NIRF imaging of cancer a very enticing prospect. Indeed, in the context of colorectal cancer, a single multimodal PET/NIRF imaging agent could be used to stage the disease, identify candidates for surgical intervention, and facilitate the image-guided resection of the disease. While antibodies have proven to be highly effective vectors for the delivery of radioisotopes and fluorophores to malignant tissues, the use of radioimmunoconjugates labeled with long-lived nuclides such as

Indexed as

AnimalsAntibodies, NeoplasmCarcinomaColorectal NeoplasmsCopper RadioisotopesDisease Models, AnimalFluorescent DyesHeterograftsMiceOptical ImagingPositron-Emission TomographyAntibodies, NeoplasmCopper RadioisotopesFluorescent Dyesbioorthogonal chemistrycolorectal carcinomafluorescence imagingmultimodal imagingPETpretargetingsite-specific bioconjugation.

Identifiers

PMID27924162
PMCPMC5135447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.