Evidence map›Paper›PMID 27924022›Full record

ArticleNucleic acids research2017

Expanded national database collection and data coverage in the FINDbase worldwide database for clinically relevant genomic variation allele frequencies.

Emmanouil Viennas, Angeliki Komianou, Clint Mizzi, Maja Stojiljkovic, Christina Mitropoulou, Juha Muilu, Mauno Vihinen, Panagiota Grypioti, Styliani Papadaki, Cristiana Pavlidis and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nucleic acids research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Balkan journal of medical genetics : BJMG · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Emmanouil ViennasUniversity of Patras, Faculty of Engineering, Department of Computer Engineering and Informatics, GR-26504, Patras, Greece.
Angeliki KomianouDepartment of Pharmacy, School of Health Sciences, University of Patras, GR-26504, Patras, Greece.
Clint MizziErasmus University Medical Center, Faculty of Medicine and Health Sciences, Department of Bioinformatics, NL-3015 CN, Rotterdam, The Netherlands.
Maja StojiljkovicInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Laboratory of Molecular Biomedicine, 11010, Belgrade, Serbia.
Christina MitropoulouThe Golden Helix Foundation, WC2N 5AP, London, UK.
Juha MuiluInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, FI-00014, Helsinki, Finland.
Mauno VihinenDepartment of Experimental Medical Science, Lund University, SE-22100, Lund, Sweden.
Panagiota GrypiotiDepartment of Pharmacy, School of Health Sciences, University of Patras, GR-26504, Patras, Greece.
Styliani PapadakiDepartment of Pharmacy, School of Health Sciences, University of Patras, GR-26504, Patras, Greece.
Cristiana PavlidisDepartment of Pharmacy, School of Health Sciences, University of Patras, GR-26504, Patras, Greece.
Branka ZukicUniversity of Malta, Faculty of Medicine and Surgery, Department of Physiology and Biochemistry, MSD 2090, Malta.
Theodora KatsilaDepartment of Pharmacy, School of Health Sciences, University of Patras, GR-26504, Patras, Greece.
Peter J van der SpekErasmus University Medical Center, Faculty of Medicine and Health Sciences, Department of Bioinformatics, NL-3015 CN, Rotterdam, The Netherlands.
Sonja PavlovicUniversity of Malta, Faculty of Medicine and Surgery, Department of Physiology and Biochemistry, MSD 2090, Malta.
Giannis TzimasDepartment of Computer and Informatics Engineering, Technological Educational Institute of Western Greece, GR-30020, Patras, Greece.
George P PatrinosDepartment of Pharmacy, School of Health Sciences, University of Patras, GR-26504, Patras, Greece gpatrinos@upatras.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

FINDbase (http://www.findbase.org) is a comprehensive data repository that records the prevalence of clinically relevant genomic variants in various populations worldwide, such as pathogenic variants leading mostly to monogenic disorders and pharmacogenomics biomarkers. The database also records the incidence of rare genetic diseases in various populations, all in well-distinct data modules. Here, we report extensive data content updates in all data modules, with direct implications to clinical pharmacogenomics. Also, we report significant new developments in FINDbase, namely (i) the release of a new version of the ETHNOS software that catalyzes development curation of national/ethnic genetic databases, (ii) the migration of all FINDbase data content into 90 distinct national/ethnic mutation databases, all built around Microsoft's PivotViewer (http://www.getpivot.com) software (iii) new data visualization tools and (iv) the interrelation of FINDbase with DruGeVar database with direct implications in clinical pharmacogenomics. The abovementioned updates further enhance the impact of FINDbase, as a key resource for Genomic Medicine applications.

Indexed as

AllelesDatabases, GeneticGene FrequencyGenetic VariationGenetic Predisposition to DiseaseGenomicsHumansPharmacogeneticsSoftwareWeb Browser

Identifiers

PMID27924022
PMCPMC5210643

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.