Evidence map›Paper›PMID 27923979›Full record

ArticlePhysiological reports2016

Functional respiratory imaging, regional strain, and expiratory time constants at three levels of positive end expiratory pressure in an ex vivo pig model.

William R Henderson, Yannick Molgat-Seon, Wim Vos, Rachel Lipson, Francisca Ferreira, Miranda Kirby, Cedric Van Holsbeke, Paolo B Dominelli, Donald E G Griesdale, Mypinder Sekhon and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06236685 (Optimizing the Assessment of Mechanical Ventilation by Integrating Advanced Monitoring Techniques), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06236685 naenrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Optimizing the Assessment of Mechanical Ventilation by Integrating Advanced Monitoring Techniques

TypeinterventionalSponsorCzech Technical University in PragueRan2024 to 2027Enrolled100ConditionsMechanical Ventilation Complication, Ventilator-Induced Lung InjuryArmsElectric impedance tomography
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

William R HendersonDivision of Critical Care Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada william.henderson@vch.ca.
Yannick Molgat-SeonSchool of Kinesiology, Vancouver, Canada.
Wim VosFluidDA, Leuven, Belgium.
Rachel LipsonEmmes Canada, Vancouver, Canada.
Francisca FerreiraFluidDA, Leuven, Belgium.
Miranda KirbyRadiology, The University of British Columbia, Vancouver, British Columbia, Canada.
Cedric Van HolsbekeFluidDA, Leuven, Belgium.
Paolo B DominelliSchool of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada.
Donald E G GriesdaleSchool of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada.
Mypinder SekhonDivision of Critical Care Medicine Vancouver General Hospital, Vancouver, British Columbia, Canada.
Harvey O CoxsonCentre for Heart Lung Innovation St Paul's Hospital University of British Columbia, Vancouver, British Columbia, Canada.
John MayoDepartment of Radiology Vancouver General Hospital University of British Columbia, Vancouver, British Columbia, Canada.
A William SheelSchool of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heterogeneity in regional end expiratory lung volume (EELV) may lead to variations in regional strain (ε). High ε levels have been associated with ventilator-associated lung injury (VALI). While both whole lung and regional EELV may be affected by changes in positive end-expiratory pressure (PEEP), regional variations are not revealed by conventional respiratory system measurements. Differential rates of deflation of adjacent lung units due to regional variation in expiratory time constants (τ

Indexed as

AnimalsFemaleImaging, Three-DimensionalLungRespiratory Function TestsRespiratory MechanicsSwineTomography, X-Ray ComputedPositive end‐expiratory pressurestraintime constant

Identifiers

PMID27923979
PMCPMC5357821

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.