ArticlePhysiological reports2016
Efficacy of nonselective optogenetic control of the medial septum over hippocampal oscillations: the influence of speed and implications for cognitive enhancement.
Article in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Medial septal theta stimulation enhances spatial working memory performance in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2025Article
- Optogenetic Stimulation of CA1 Pyramidal Neurons at Theta Enhances Recognition Memory in Brain Injured Animals.Journal of neurotrauma · 2023Article
- Linking temporal coordination of hippocampal activity to memory function.Frontiers in cellular neuroscience · 2023Review
- Optogenetic "low-theta" pacing of the septohippocampal circuit is sufficient for spatial goal finding and is influenced by behavioral state and cognitive demand.Hippocampus · 2020Article
- The medial septum enhances reversal learning via opposing actions on ventral tegmental area and substantia nigra dopamine neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Optogenetic Stimulation of the Basolateral Amygdala Increased Theta-Modulated Gamma Oscillations in the Hippocampus.Frontiers in behavioral neuroscience · 2019Article
- Medial septum differentially regulates dopamine neuron activity in the rat ventral tegmental area and substantia nigra via distinct pathways.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice.Journal of visualized experiments : JoVE · 2018Article
- Hippocampal Neural Circuits Respond to Optogenetic Pacing of Theta Frequencies by Generating Accelerated Oscillation Frequencies.Current biology : CB · 2018Article
- Experience-dependent trends in CA1 theta and slow gamma rhythms in freely behaving mice.Journal of neurophysiology · 2018Article
- Efficacy of nonselective optogenetic control of the medial septum over hippocampal oscillations: the influence of speed and implications for cognitive enhancement.Physiological reports · 2016Article
- Disruption of hippocampal rhythms via optogenetic stimulation during the critical period for memory development impairs spatial cognition.Brain stimulationArticle
Corrections and comments
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Authors and funding
7 authors.
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Abstract
Optogenetics holds great promise for both the dissection of neural circuits and the evaluation of theories centered on the temporal organizing properties of oscillations that underpin cognition. To date, no studies have examined the efficacy of optogenetic stimulation for altering hippocampal oscillations in freely moving wild-type rats, or how these alterations would affect performance on behavioral tasks. Here, we used an AAV virus to express ChR2 in the medial septum (MS) of wild-type rats, and optically stimulated septal neurons at 6 Hz and 30 Hz. We measured the corresponding effects of these stimulations on the oscillations of the MS and hippocampal subfields CA1 and CA3 in three different contexts: (1) With minimal movement while the rats sat in a confined chamber; (2) Explored a novel open field; and (3) Learned and performed a T-maze behavioral task. While control yellow light stimulation did not affect oscillations, 6-Hz blue light septal stimulations altered hippocampal theta oscillations in a manner that depended on the animal's mobility and speed. While the 30 Hz blue light septal stimulations only altered theta frequency in CA1 while the rat had limited mobility, it robustly increased the amplitude of hippocampal signals at 30 Hz in both regions in all three recording contexts. We found that animals were more likely to make a correct choice during Day 1 of T-maze training during both MS stimulation protocols than during control stimulation, and that improved performance was independent of theta frequency alterations.
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