ArticleThe Journal of experimental medicine2017
CD4+ T cell effector commitment coupled to self-renewal by asymmetric cell divisions.
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Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
What it found
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Who cites it
79 citing papers in PubMed, 111 citations in OpenAlex.
- Monocytic niches escape T cell surveillance and promote Mycobacterium tuberculosis persistence in lymph nodes.Immunity · 2026Article
- Stem-like CD4 T cells in tumors: an emerging framework for antitumor immunity.Frontiers in immunology · 2026Review
- Splicing-aware scRNA-Seq resolution reveals execution-ready programs in effector Tregs.PLoS computational biology · 2025Article
- Beyond T-cell subsets: stemness and adaptation redefining immunity and immunotherapy.Cellular & molecular immunology · 2025Review
- Plasmodium falciparum infection induces T cell tolerance that is associated with decreased disease severity upon re-infection.The Journal of experimental medicine · 2025Article
- Immune regeneration: implications for cancer immunotherapy and beyond.The Journal of clinical investigation · 2025Review
- OCA-B promotes pathogenic maturation of stem-like CD4+ T cells and autoimmune demyelination.The Journal of clinical investigation · 2025Article
- Rhinovirus as a driver of airway T cell dynamics in children with treatment-refractory recurrent wheeze.JCI insight · 2025Article
- Regulatory T cells constrain T cells of shared specificity to enforce tolerance during infection.Science (New York, N.Y.) · 2025Article
- Combination adjuvant improves influenza virus immunity by downregulation of immune homeostasis genes in lymphocytes.ImmunoHorizons · 2025Article
- Simultaneous single-cell analysis of 5mC and 5hmC with SIMPLE-seq.Nature biotechnology · 2025Article
- DEFA5-producing CD4Frontiers in immunology · 2025Article
- Advances and challenges in identifying precursors of memory CD4Frontiers in immunology · 2025Review
- A pathologically expanded, clonal lineage of IL-21-producing CD4+ T cells drives inflammatory neuropathy.The Journal of clinical investigation · 2024Article
- Recruitment and Maintenance of CX3CR1+CD4+ T Cells during Helminth Infection.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- A pathologically expanded, clonal lineage of IL-21 producing CD4+ T cells drives Inflammatory neuropathy.bioRxiv : the preprint server for biology · 2024Article
- Asymmetric T-cell division: insights from cutting-edge experimental techniques and implications for immunotherapy.Frontiers in immunology · 2024Review
- High density of TCF1+ stem-like tumor-infiltrating lymphocytes is associated with favorable disease-specific survival in NSCLC.Frontiers in immunology · 2024Article
- BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia.PLoS pathogens · 2024Article
- Intestinal microbiota-specific Th17 cells possess regulatory properties and suppress effector T cells via c-MAF and IL-10.Immunity · 2023Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Simone A NishDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.ORCID 0000-0002-9070-1796
Kyra D ZensColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032.ORCID 0000-0001-7979-076X
Radomir KratchmarovDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Wen-Hsuan W LinDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.ORCID 0000-0002-5414-7900
William C AdamsDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Yen-Hua ChenDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.ORCID 0000-0002-8880-5684
Bonnie YenDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.ORCID 0000-0003-0653-863X
Nyanza J RothmanDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032.ORCID 0000-0002-9707-2283
Avinash BhandoolaT-Cell Biology and Development Unit, Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892.
Hai-Hui XueDepartment of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
Donna L FarberColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY 10032.
Steven L ReinerDepartment of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032 sr2978@cumc.columbia.edu.ORCID 0000-0002-1635-8619
Columbia University · USColumbia University Irving Medical Center · USNational Cancer Institute · USUniversity of Iowa · US
Funding
Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Parisa Tehranifar · 1985 to 2026
$115.3MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007367 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI REINER, STEVEN L · 1985 to 2021
$25.1MT cell Development and RegenerationZIABC011633 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BHANDOOLA, AVINASH · 2015 to 2025
$20.5MTcf/Lef-b-catenin in T cell identity and cancerR01AI112579 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2015 to 2026
$5.4MTcf/Lef and B-catenin pathway in follicular helper T cellsR01AI121080 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2016 to 2026
$4.6MControl of CD8+ Effector T Cell DifferentiationR01AI061699 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI REINER, STEVEN L · 2005 to 2015
$4.0MAsymmetric Lymphocyte Division in the Immune ResponseR01AI076458 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI REINER, STEVEN L · 2008 to 2019
$3.7MColumbia University Graduate Training Program in Microbiology and ImmunologyT32AI106711 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Nicholas Arpaia, Uttiya Basu · 2014 to 2026
$2.1MDiversifying and Regenerating T Cell FunctionR01AI113365 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REINER, STEVEN L · 2014 to 2018
$2.0MLung resident niches for memory CD4 T cellsR01HL116136 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FARBER, DONNA L. · 2015 to 2018
$1.6MSelf-renewing Lymphocyte Division in The Immune ResponseR56AI076458 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REINER, STEVEN L · 2014 to 2021
$802kEpigenomic landscape in naive, effector, and memory CD8 T cellsR21AI115149 · NIAID · UNIVERSITY OF IOWA · PI TAN, KAI, XUE, HAI-HUI · 2015 to 2016
$417kBLRD VA I01 BX002903NCI NIH HHS P30 CA013696NHLBI NIH HHS R01 HL116136NIAID NIH HHS R01 AI061699NIAID NIH HHS R01 AI076458NIAID NIH HHS R01 AI112579NIAID NIH HHS R01 AI113365NIAID NIH HHS R01 AI121080NIAID NIH HHS R21 AI115149NIAID NIH HHS R21 AI119160NIAID NIH HHS R56 AI076458NIAID NIH HHS T32 AI106711NIGMS NIH HHS T32 GM007367
Abstract
Upon infection, an activated CD4
Indexed as
AnimalsAsymmetric Cell DivisionCD4-Positive T-LymphocytesCell DivisionCells, CulturedHepatocyte Nuclear Factor 1-alphaMiceMice, Inbred C57BLPhosphatidylinositol 3-KinasesTOR Serine-Threonine KinasesHepatocyte Nuclear Factor 1-alphaHnf1a protein, mousemTOR protein, mousePhosphatidylinositol 3-KinasesTOR Serine-Threonine Kinases
Identifiers
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LicenceCC BY-NC-SA
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.