ArticleThe Plant cell2016
Orosomucoid Proteins Interact with the Small Subunit of Serine Palmitoyltransferase and Contribute to Sphingolipid Homeostasis and Stress Responses in Arabidopsis.
Article in The Plant cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 71 citations in OpenAlex.
- ORMDL Proteins Turnover via Proteasome and Autophagy Is Cell-Type Dependent and Tied to Ceramide Homeostasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Integrated transcriptome and metabolome analysis reveals key genes and metabolic pathways regulating growth and development inFrontiers in plant science · 2026Article
- Single-cell transcriptome sequencing reveals the sphingolipid metabolism pathway plays an important role in leaf senescence in tobacco.BMC plant biology · 2025Article
- Ceramides play a significant role in the response of Pogostemon cablin to bacterial wilt by regulating the ABA pathway.BMC plant biology · 2025Article
- Sphingosine Promotes Fiber Early Elongation in Upland Cotton.Plants (Basel, Switzerland) · 2024Article
- Normal and Dysregulated Sphingolipid Metabolism: Contributions to Podocyte Injury and Beyond.Cells · 2024Review
- OROSOMUCOID PROTEIN 1 regulation of sphingolipid synthesis is required for nodulation in Aeschynomene evenia.Plant physiology · 2024Article
- PatWRKY71 transcription factor regulates patchoulol biosynthesis and plant defense response.BMC plant biology · 2024Article
- Mechanism of sphingolipid homeostasis revealed by structural analysis ofScience advances · 2023Article
- Engineering plant immune circuit: walking to the bright future with a novel toolbox.Plant biotechnology journal · 2023Review
- Diversity in sphingolipid metabolism across land plants.Journal of experimental botany · 2022Review
- Sphingolipid-Induced Programmed Cell Death is a Salicylic Acid and EDS1-Dependent Phenotype in Arabidopsis Fatty Acid Hydroxylase (Fah1, Fah2) and Ceramide Synthase (Loh2) Triple Mutants.Plant & cell physiology · 2022Article
- Jasmonates modulate sphingolipid metabolism and accelerate cell death in the ceramide kinase mutant acd5.Plant physiology · 2021Article
- Functions of Sphingolipids in Pathogenesis During Host-Pathogen Interactions.Frontiers in microbiology · 2021Review
- Dissecting the regulatory roles of ORM proteins in the sphingolipid pathway of plants.PLoS computational biology · 2021Article
- The Distribution and Origins ofFrontiers in plant science · 2021Article
- Unregulated Sphingolipid Biosynthesis in Gene-Edited ArabidopsisThe Plant cell · 2020Article
- A Pyrimidin-Like Plant Activator Stimulates Plant Disease Resistance and Promotes the Synthesis of Primary Metabolites.International journal of molecular sciences · 2020Article
- Multiple Functions of ATG8 Family Proteins in Plant Autophagy.Frontiers in cell and developmental biology · 2020Review
- Ceramide-Induced Cell Death Depends on Calcium and Caspase-Like Activity in Rice.Frontiers in plant science · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serine palmitoyltransferase (SPT), a pyridoxyl-5'-phosphate-dependent enzyme, catalyzes the first and rate-limiting step in sphingolipid biosynthesis. In humans and yeast, orosomucoid proteins (ORMs) negatively regulate SPT and thus play an important role in maintaining sphingolipid levels. Despite the importance of sphingoid intermediates as bioactive molecules, the regulation of sphingolipid biosynthesis through SPT is not well understood in plants. Here, we identified and characterized the Arabidopsis thaliana ORMs, ORM1 and ORM2. Loss of function of both ORM1 and ORM2 (orm1 amiR-ORM2) stimulated de novo sphingolipid biosynthesis, leading to strong sphingolipid accumulation, especially of long-chain bases and ceramides. Yeast two-hybrid, bimolecular fluorescence complementation, and coimmunoprecipitation assays confirmed that ORM1 and ORM2 physically interact with the small subunit of SPT (ssSPT), indicating that ORMs inhibit ssSPT function. We found that orm1 amiR-ORM2 plants exhibited an early-senescence phenotype accompanied by H
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.