ArticleCerebral cortex (New York, N.Y. : 1991)2017
An Examination of the Neural Unreliability Thesis of Autism.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is functional brain connectivity atypical in autism? A systematic review of EEG and MEG studies.PloS one · 2017Pooled it
- The role of single trial variability in event related potentials in children with attention deficit hyperactivity disorder.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Trial
- Visual Responsivity in Autism: Measuring Visual Responses in Autistic and Non-Autistic Adults Using Psychophysics, fMRI, and EEG.Autism research : official journal of the International Society for Autism Research · 2026Article
- A Multimodal Framework for Understanding Perceptual Segmentation of Natural Scenes In Autism.bioRxiv : the preprint server for biology · 2025Article
- Harnessing Trial-to-Trial Variability of EEG Spectral Characteristics to Understand Autism.Journal of autism and developmental disorders · 2025Article
- High neural noise in autism: A hypothesis currently at the nexus of explanatory power.Heliyon · 2024Review
- Article
- Probing a neural unreliability account of auditory sensory processing atypicalities in Rett Syndrome.Journal of neurodevelopmental disorders · 2024Article
- "Neural Noise" in Auditory Responses in Young Autistic and Neurotypical Children.Journal of autism and developmental disorders · 2024Article
- Design and methodology for a proof of mechanism study of individualized neuronavigated continuous Theta burst stimulation for auditory processing in adolescents with autism spectrum disorder.Frontiers in psychiatry · 2024Article
- Assessing Trial-to-Trial Variability in Auditory ERPs in Autism and Schizophrenia.Journal of autism and developmental disorders · 2023Article
- Severely Attenuated Visual Feedback Processing in Children on the Autism Spectrum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Does stochastic resonance improve performance for individuals with higher autism-spectrum quotient?Frontiers in neuroscience · 2023Article
- Internal noise measures in coarse and fine motion direction discrimination tasks and the correlation with autism traits.Journal of vision · 2022Article
- Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Increased context adjustment is associated with auditory sensitivities but not with autistic traits.Autism research : official journal of the International Society for Autism Research · 2022Article
- Altered EEG variability on different time scales in participants with autism spectrum disorder: an exploratory study.Scientific reports · 2022Article
- Attentional influences on neural processing of biological motion in typically developing children and those on the autism spectrum.Molecular autism · 2022Article
- Oscillatory entrainment mechanisms and anticipatory predictive processes in children with autism spectrum disorder.Journal of neurophysiology · 2021Article
- Looking for consistency in an uncertain world: test-retest reliability of neurophysiological and behavioral readouts in autism.Journal of neurodevelopmental disorders · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
An emerging neuropathological theory of Autism, referred to here as "the neural unreliability thesis," proposes greater variability in moment-to-moment cortical representation of environmental events, such that the system shows general instability in its impulse response function. Leading evidence for this thesis derives from functional neuroimaging, a methodology ill-suited for detailed assessment of sensory transmission dynamics occurring at the millisecond scale. Electrophysiological assessments of this thesis, however, are sparse and unconvincing. We conducted detailed examination of visual and somatosensory evoked activity using high-density electrical mapping in individuals with autism (N = 20) and precisely matched neurotypical controls (N = 20), recording large numbers of trials that allowed for exhaustive time-frequency analyses at the single-trial level. Measures of intertrial coherence and event-related spectral perturbation revealed no convincing evidence for an unreliability account of sensory responsivity in autism. Indeed, results point to robust, highly reproducible response functions marked for their exceedingly close correspondence to those in neurotypical controls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.