Evidence map›Paper›PMID 27923836›Full record

ArticleCancer research2017

The SWI/SNF Complex Protein Snr1 Is a Tumor Suppressor in

Gengqiang Xie, Hanqing Chen, Dongyu Jia, Zhiqiang Shu, William Hunt Palmer, Yi-Chun Huang, Xiankun Zeng, Steven X Hou, Renjie Jiao, Wu-Min Deng

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Leptin Acts as a Peripheral Tropic Signal to Tune Steroidogenesis.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Notch Signaling in Drosophila Tumor Models.Advances in experimental medicine and biology · 2025
    Review
  4. Epigenetic Regulation in Drosophila Tumor Models.Advances in experimental medicine and biology · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Tumor models in various Drosophila tissues.WIREs mechanisms of disease · 2021
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Modelling Cooperative Tumorigenesis inBioMed research international · 2018
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Gengqiang XieDepartment of Biological Science, Florida State University, Tallahassee, Florida.
Hanqing ChenState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, the Chinese Academy of Sciences, Beijing, China.
Dongyu JiaDepartment of Biological Science, Florida State University, Tallahassee, Florida.
Zhiqiang ShuDepartment of Biological Science, Florida State University, Tallahassee, Florida.
William Hunt PalmerDepartment of Biological Science, Florida State University, Tallahassee, Florida.
Yi-Chun HuangDepartment of Biological Science, Florida State University, Tallahassee, Florida.
Xiankun ZengThe Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Frederick, Maryland.
Steven X HouThe Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Frederick, Maryland.
Renjie JiaoState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, the Chinese Academy of Sciences, Beijing, China. wumin@bio.fsu.edu rjiao@sun5.ibp.ac.cn.
Wu-Min DengDepartment of Biological Science, Florida State University, Tallahassee, Florida. wumin@bio.fsu.edu rjiao@sun5.ibp.ac.cn.
Florida State University · USInstitute of Biophysics · CNNational Institutes of Health · US

Funding

Molecular Genetic Study of Stem Cells, Cancer Stem Cells, and Stem Cell AgingZIABC010738 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HOU, STEVEN · 2009 to 2020
$14.4M
Notch signaling and germline-soma interactions in the Drosophila ovarian modelR01GM072562 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI DENG, WU-MIN · 2006 to 2025
$5.6M
Molecular Genetic Study of Stem Cells, Cancer Stem Cells, and Stem Cell AgingZ01BC010738 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HOU, XIANYU S · 2006 to 2008
$2.7M
Intramural NIH HHS Z01 BC010738NIGMS NIH HHS R01 GM072562
6 · The paper itself

Abstract

Components of the SWI/SNF chromatin-remodeling complex are among the most frequently mutated genes in various human cancers, yet only SMARCB1/hSNF5, a core member of the SWI/SNF complex, is mutated in malignant rhabdoid tumors (MRT). How SMARCB1/hSNF5 functions differently from other members of the SWI/SNF complex remains unclear. Here, we use

Indexed as

AnimalsDrosophila melanogasterDrosophila ProteinsEndosomesImaginal DiscsMAP Kinase Signaling SystemReceptors, NotchSignal TransductionSMARCB1 ProteinSTAT Transcription FactorsTranscription FactorsTumor Suppressor ProteinsDrosophila ProteinsN protein, DrosophilaReceptors, NotchSMARCB1 ProteinSnr1 protein, DrosophilaSTAT Transcription FactorsTranscription FactorsTumor Suppressor Proteins

Identifiers

PMID27923836
PMCPMC7885033
OpenAlexW2559846904

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.