Evidence map›Paper›PMID 27923833›Full record

ArticleCancer research2017

An Essential Role of

Sijana H Dzinic, M Margarida Bernardo, Xiaohua Li, Rodrigo Fernandez-Valdivia, Ye-Shih Ho, Qing-Sheng Mi, Sudeshna Bandyopadhyay, Fulvio Lonardo, Semir Vranic, Daniel S M Oliveira and 15 more

Open access · greenAbstract read
In one paragraph

Article in Cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 1 institution in 1 country.

Sijana H DzinicDepartment of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
M Margarida BernardoDepartment of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
Xiaohua LiDepartment of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
Rodrigo Fernandez-ValdiviaDepartment of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
Ye-Shih HoInstitute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, Michigan.
Qing-Sheng MiTumor Biology and Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.
Sudeshna BandyopadhyayDepartment of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
Fulvio LonardoDepartment of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
Semir VranicDivision of Experimental Pathology, Department of Pathology, University Clinical Center, Sarajevo, Bosnia and Herzegovina.
Daniel S M OliveiraDepartment of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
R Daniel BonfilDepartment of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
Gregory DysonTumor Biology and Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.
Kang ChenTumor Biology and Microenvironment Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan.
Almasa OmerovicDepartment of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
Xiujie ShengDepartment of Obstetrics and Gynecology, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, P.R. China.
Xiang HanPeking University Health Science Center, The Third Affiliated Hospital, Beijing, P.R. China.
Dinghong WuDepartment of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan.
Xinling BiDepartment of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan.
Dzenana CabaravdicDepartment of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
Una JakupovicDepartment of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
Marian WahbaDepartment of Internal Medicine, Sinai Grace Hospital, Detroit Medical Center, Detroit, Michigan.
Aaron PangDepartment of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
Deanna HarajliDepartment of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
Wael A SakrDepartment of Pathology, Wayne State University School of Medicine, Detroit, Michigan.
Shijie ShengDepartment of Pathology, Wayne State University School of Medicine, Detroit, Michigan. ssheng@med.wayne.edu.
Wayne State University · US

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4M
The therapeutic potential of maspin in prostate cancerR01CA084176 · NCI · WAYNE STATE UNIVERSITY · PI SHENG, SHIJIE · 2001 to 2011
$2.7M
A Role of Novel Serpin Maspinin Prostate Tumor/Bone InteractionR01CA127735 · NCI · WAYNE STATE UNIVERSITY · PI SHENG, SHIJIE · 2008 to 2012
$1.5M
NCI NIH HHS P30 CA022453NCI NIH HHS R01 CA084176NCI NIH HHS R01 CA127735
6 · The paper itself

Abstract

Maspin (SerpinB5) is an epithelial-specific tumor suppressor gene product that displays context-dependent cellular functions. Maspin-deficient mouse models created to date have not definitively established maspin functions critical for cancer suppression. In this study, we generated a mouse strain in which exon 4 of the

Indexed as

Embryonic DevelopmentAlopecia AreataAnimalsFemaleHistone Deacetylase 1MaleMammary Glands, AnimalMiceMice, Inbred C57BLOrgan SpecificityProstateSerpinsTumor Suppressor ProteinsHdac1 protein, mouseHistone Deacetylase 1SERPIN-B5SerpinsTumor Suppressor Proteins

Identifiers

PMID27923833
PMCPMC5313336
OpenAlexW2560373565

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.