Evidence map›Paper›PMID 27923813›Full record

ArticleThe Journal of biological chemistry2017

The Chemical Basis of Thiol Addition to Nitro-conjugated Linoleic Acid, a Protective Cell-signaling Lipid.

Lucía Turell, Darío A Vitturi, E Laura Coitiño, Lourdes Lebrato, Matías N Möller, Camila Sagasti, Sonia R Salvatore, Steven R Woodcock, Beatriz Alvarez, Francisco J Schopfer

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Lipoxin AbioRxiv : the preprint server for biology · 2024
    Article
  8. Article
  9. Article
  10. Nitro Fatty Acids (NOMolecules (Basel, Switzerland) · 2021
    Review
  11. Review
  12. Article
  13. Article
  14. Nitro-fatty acids as activators of hSIRT6 deacetylase activity.The Journal of biological chemistry · 2020
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Nitrated fatty acids: from diet to disease.Current opinion in physiology · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Lucía TurellFrom the Laboratorios de Enzimología.
Darío A Vitturithe Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
E Laura CoitiñoQuímica Teórica y Computacional, and.
Lourdes LebratoFrom the Laboratorios de Enzimología.
Matías N MöllerCenter for Free Radical and Biomedical Research, Universidad de la República, Montevideo 11400, Uruguay and.
Camila SagastiQuímica Teórica y Computacional, and.
Sonia R Salvatorethe Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Steven R Woodcockthe Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213.
Beatriz AlvarezFrom the Laboratorios de Enzimología, beatriz.alvarez@fcien.edu.uy.
Francisco J Schopferthe Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 fjs2@pitt.edu.
Universidad de la República · UYUniversity of Pittsburgh · US

Funding

Protection against sickle cell disease nephropathy by nitrated fatty acidsK01HL133331 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VITTURI, DARIO A · 2016 to 2021
$848k
NHLBI NIH HHS K01 HL133331
6 · The paper itself

Abstract

Nitroalkene fatty acids are formed in vivo and exert protective and anti-inflammatory effects via reversible Michael addition to thiol-containing proteins in key signaling pathways. Nitro-conjugated linoleic acid (NO

Indexed as

Signal TransductionHumansLinoleic AcidNitro CompoundsSerum AlbuminSulfhydryl CompoundsLinoleic AcidNitro CompoundsSerum AlbuminSulfhydryl Compoundsalbuminconjugated nitrolinoleic acideliminationfatty acidkineticsMichael additionnitroalkene fatty acidnitro fatty acidsulfhydrylthiol

Identifiers

PMID27923813
PMCPMC5270462
OpenAlexW2560836594

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.