Evidence map›Paper›PMID 27923789›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2017

Influence of sympathetic nerve activity on aortic hemodynamics and pulse wave velocity in women.

Ronée E Harvey, Jill N Barnes, Emma C J Hart, Wayne T Nicholson, Michael J Joyner, Darren P Casey

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 56 citations in OpenAlex.

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  4. Role of the carotid chemoreceptors in insulin-mediated sympathoexcitation in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020
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  17. Impact of age and cyclooxygenase inhibition on the hemodynamic response to acute cognitive challenges.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Ronée E HarveyMayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota.
Jill N BarnesDepartment of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin.
Emma C J HartUniversity of Bristol, Bristol, United Kingdom.
Wayne T NicholsonDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota; and.
Michael J JoynerDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota; and.
Darren P CaseyDepartment of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, Iowa darren-casey@uiowa.edu.
Mayo Clinic · USUniversity of Bristol · GBUniversity of Iowa · USUniversity of Wisconsin–Madison · US

Funding

Sex-specific Risk for Vascular Dysfunction and Cognitive DeclineP50AG044170 · NIA · MAYO CLINIC ROCHESTER · PI MILLER, VIRGINIA M · 2012 to 2017
$6.1M
Neurovascular Control and Blood Pressure Regulation in HumansR01HL083947 · NHLBI · MAYO CLINIC ROCHESTER · PI JOYNER, MICHAEL J · 2007 to 2016
$3.6M
Cerebral blood flow, connectivity and cognition: the effect of age and exerciseK99HL118154 · NHLBI · MAYO CLINIC ROCHESTER · PI BARNES, JILL NICOLE · 2014 to 2015
$180k
British Heart Foundation FS/11/1/28400NHLBI NIH HHS K99 HL118154NHLBI NIH HHS R01 HL083947NIA NIH HHS P50 AG044170
6 · The paper itself

Abstract

Central (aortic) blood pressure, arterial stiffness, and sympathetic nerve activity increase with age in women. However, it is unknown if the age-related increase in sympathetic activity influences aortic hemodynamics and carotid-femoral pulse wave velocity (cfPWV), an index of central aortic stiffness. The goal of this study was to determine if aortic hemodynamics and cfPWV are directly influenced by sympathetic nerve activity by measuring aortic hemodynamics, cfPWV, and muscle sympathetic nerve activity (MSNA) in women before and during autonomic ganglionic blockade with trimethaphan camsylate. We studied 12 young premenopausal (23 ± 4 yr) and 12 older postmenopausal (57 ± 3 yr) women. These women did not differ in body mass index or mean arterial pressure (

Indexed as

Pulse Wave AnalysisAdultAgingAortaArterial PressureFemaleGanglia, AutonomicGanglionic BlockersHeart RateHemodynamicsHumansInfusions, IntravenousMiddle AgedMuscle, SkeletalPostmenopausePremenopauseGanglionic BlockersTrimethaphantrimethaphan camsylateVasodilator Agentsagingarterial stiffnessautonomic nervous systemcentral hemodynamicsmenopause

Identifiers

PMID27923789
PMCPMC5336574
OpenAlexW2560174632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.