ReviewAmerican journal of physiology. Heart and circulatory physiology2017
Retinal microvascular network alterations: potential biomarkers of cerebrovascular and neural diseases.
Review in American journal of physiology. Heart and circulatory physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Ocular markers of microangiopathy and their possible association with cardiovascular risk in patients with systemic inflammatory rheumatic diseases: a systematic review.Frontiers in immunology · 2025Pooled it
- Effects of Physical Exercise Breaks on Executive Function in a Simulated Classroom Setting: Uncovering a Window into the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Trial
- Effect of obstructive sleep apnoea on retinal microvascular function: a randomised controlled trial.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Trial
- Metabolic reprogramming in diabetic panvascular disease: Molecular mechanism and therapeutic strategies.iScience · 2026Review
- The Underutilized Ocular Fundus in Emergency Departments: Current Progress and Future Prospect of Imaging and Artificial Intelligence for Patient Care.Ophthalmology science · 2026Review
- Subclinical ocular microvascular involvement in primary antiphospholipid syndrome and antiphospholipid antibody carriers.Lupus science & medicine · 2026Article
- Dynamic and Structural Retinal Microvascular Alterations After Radiation Exposure: Insights From a Large-Animal Model.Investigative ophthalmology & visual science · 2026Article
- Retinal Microvascular Alterations in Diabetic Patients Assessed with Novel Imaging Techniques.Life (Basel, Switzerland) · 2026Review
- A novel electrocardiogram-synchronized laser Doppler holography system for cardiac cycle-resolved retinal hemodynamics: development and validation.Scientific reports · 2026Article
- Circulating Claudin-5 and Systemic Inflammatory Indices in Wet and Dry Age-Related Macular Degeneration.Medicina (Kaunas, Lithuania) · 2026Article
- Retinal Microvasculature and Emotional, Behavioral, and Cognitive Outcomes at School Age.Journal of the American Heart Association · 2026Article
- Cortical layer multi-parameter analysis of neurovascular impairments in AD/ADRD rodent model with in vivo optical imaging.Translational neurodegeneration · 2025Article
- Article
- Retinal microvascular alterations in motoric cognitive risk syndrome: an OCT angiography study.International ophthalmology · 2025Observational
- Relationships between multimodal ocular imaging and white matter hyperintensity volume.Quantitative imaging in medicine and surgery · 2025Article
- Exploring Endothelial Cell Dysfunction's Impact on the Brain-Retina Microenvironment Connection: Molecular Mechanisms and Implications.Molecular neurobiology · 2025Review
- Assessment of individual retinal layer thickness and vascular changes in Alzheimer's disease.Scientific reports · 2025Article
- Development of the European Society of Hypertension guidelines for the management of arterial hypertension: comparison of the helpfulness of ESH 2013, 2018, and 2023 guidelines.Journal of hypertension · 2025Article
- A Novel Nomogram Integrating Retinal Microvasculature and Clinical Indicators for Individualized Prediction of Early Neurological Deterioration in Single Subcortical Infarction.CNS neuroscience & therapeutics · 2025Observational
- Retinal vascular geometry and its association to silent brain infarction.BMC ophthalmology · 2025Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence suggests that the conditions of retinal microvessels are indicators to a variety of cerebrovascular, neurodegenerative, psychiatric, and developmental diseases. Thus noninvasive visualization of the human retinal microcirculation offers an exceptional opportunity for the investigation of not only the retinal but also cerebral microvasculature. In this review, we show how the conditions of the retinal microvessels could be used to assess the conditions of brain microvessels because the microvascular network of the retina and brain share, in many aspects, standard features in development, morphology, function, and pathophysiology. Recent techniques and imaging modalities, such as optical coherence tomography (OCT), allow more precise visualization of various layers of the retina and its microcirculation, providing a "microscope" to brain microvessels. We also review the potential role of retinal microvessels in the risk identification of cerebrovascular and neurodegenerative diseases. The association between vision problems and cerebrovascular and neurodegenerative diseases, as well as the possible role of retinal microvascular imaging biomarkers in cerebrovascular and neurodegenerative screening, their potentials, and limitations, are also discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.