Evidence map›Paper›PMID 27923718›Full record

ReviewPhysiology & behavior2017

Using the cerebrospinal fluid to understand ingestive behavior.

Stephen C Woods, Aaron A May, Min Liu, Patrick Tso, Denovan P Begg

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Physiology & behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stephen C WoodsDepartment of Psychiatry and Behavioral Neuroscience, Metabolic Diseases Institute, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: steve.woods@uc.edu.
Aaron A MayDepartment of Pathology and Molecular Medicine, Metabolic Diseases Institute, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Min LiuDepartment of Pathology and Molecular Medicine, Metabolic Diseases Institute, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Patrick TsoDepartment of Pathology and Molecular Medicine, Metabolic Diseases Institute, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Denovan P BeggSchool of Psychology, University of New South Wales, Sydney, NSW 2052, Australia.

Funding

TRAINING IN GASTROENTEROLOGYT32DK007673 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 1992 to 2026
$8.4M
Lipid profile, lipoprotein and apolipoprotein composition, and intestinal fat absorption efficiency in germ-free and conventional miceU2CDK059630 · NIDDK · UNIVERSITY OF CINCINNATI · PI LIU, MIN · 2016 to 2021
$4.9M
INSULIN AND CNS CONTROL OF BODY WEIGHT AND FOOD INTAKER01DK017844 · NIDDK · UNIVERSITY OF WASHINGTON · PI WOODS, STEPHEN C · 1986 to 2013
$3.8M
Training Program in Neuroendocrinology of HomeostasisT32DK059803 · NIDDK · UNIVERSITY OF CINCINNATI · PI WOODS, STEPHEN C · 2001 to 2017
$2.8M
Apolipoprotein AV and intestinal transportR01DK103557 · NIDDK · UNIVERSITY OF CINCINNATI · PI TSO, PATRICK · 2015 to 2019
$1.9M
Brain apoA-IV Mediates Estrogenic Reduction of Dietary Obesity in Female RatsR01DK092779 · NIDDK · UNIVERSITY OF CINCINNATI · PI LIU, MIN, WOODS, STEPHEN C · 2011 to 2015
$1.8M
Ginsenocide Rb1: A Novel Anti-Obesity and Anti-Hyperglycemic CompoundR01DK095440 · NIDDK · UNIVERSITY OF CINCINNATI · PI LIU, MIN, WOODS, STEPHEN C · 2012 to 2016
$1.6M
INSULIN AND CNS CONTROL OF BODY WEIGHT AND FOOD INTAKER37DK017844 · NIDDK · UNIVERSITY OF WASHINGTON · PI WOODS, STEPHEN C · 1993 to 2000
$382k
NIDDK NIH HHS R01 DK017844NIDDK NIH HHS R01 DK092779NIDDK NIH HHS R01 DK095440NIDDK NIH HHS R01 DK103557NIDDK NIH HHS R37 DK017844NIDDK NIH HHS T32 DK007673NIDDK NIH HHS T32 DK059803NIDDK NIH HHS U2C DK059630
6 · The paper itself

Abstract

The cerebrospinal fluid (CSF) offers a window into the workings of the brain and blood-brain barrier (BBB). Molecules that enter into the central nervous system (CNS) by passive diffusion or receptor-mediated transport through the choroid plexus often appear in the CSF prior to acting within the brain. Other molecules enter the CNS by passing through the BBB into the brain's interstitial fluid prior to appearing in the CSF. This pattern is also often observed for molecules synthesized by neurons or glia within the CNS. The CSF is therefore an important conduit for the entry and clearance of molecules into/from the CNS and thereby constitutes an important window onto brain activity and barrier function. Assessing the CSF basally, under experimental conditions, or in the context of challenges or metabolic diseases can provide powerful insights about brain function. Here, we review important findings made by our labs, as influenced by the late Randall Sakai, by interrogating the CSF.

Indexed as

AnimalsBrainCerebrospinal FluidFeeding BehaviorHumansInsulinInsulinBehavioral endocrinologyBlood-brain barrierCerebrospinal fluidFood intakeInsulinSatiation signals

Identifiers

PMID27923718
PMCPMC5944842

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.