ArticleResuscitation2017
A hemodynamic-directed approach to pediatric cardiopulmonary resuscitation (HD-CPR) improves survival.
Article in Resuscitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed.
- Chest compressions superimposed with sustained inflations during cardiopulmonary resuscitation in asphyxiated pediatric piglets.Pediatric research · 2024Trial
- Trial
- Key physiological indicators and technological trends in physiology-directed cardiopulmonary resuscitation: A narrative review.Resuscitation plus · 2026Review
- Physiologic response to sodium bicarbonate administration during pediatric in-hospital cardiac arrest.Frontiers in medicine · 2026Article
- Evaluation of coronary perfusion pressure and diastolic blood pressure calculation methods in a swine model of pediatric cardiopulmonary resuscitation.Resuscitation plus · 2025Article
- Association of diastolic blood pressure with coronary perfusion pressure during resuscitation in pediatric swine.Pediatric research · 2025Article
- A novel translational bioinformatics framework for facilitating multimodal data analyses in preclinical models of neurological injury.Scientific reports · 2024Article
- Amplitude spectrum area is dependent on the electrocardiogram magnitude: evaluation of different normalization approaches.Physiological measurement · 2024Article
- Elevated serum neurologic biomarker profiles after cardiac arrest in a porcine model.Resuscitation plus · 2024Article
- Effect of dimethyl fumarate on mitochondrial metabolism in a pediatric porcine model of asphyxia-induced in-hospital cardiac arrest.Scientific reports · 2024Article
- Wolf Creek XVII part 9: Wolf Creek Innovator in Cardiac Arrest and Resuscitation Science Award.Resuscitation plus · 2024Review
- Animal research in cardiac arrest.Resuscitation plus · 2024Review
- Associations Between End-Tidal Carbon Dioxide During Pediatric Cardiopulmonary Resuscitation, Cardiopulmonary Resuscitation Quality, and Survival.Circulation · 2024Observational
- The association of arterial blood pressure waveform-derived area duty cycle with intra-arrest hemodynamics and cardiac arrest outcomes.Resuscitation · 2023Article
- Prediction of Return of Spontaneous Circulation in a Pediatric Swine Model of Cardiac Arrest Using Low-Resolution Multimodal Physiological Waveforms.IEEE journal of biomedical and health informatics · 2023Article
- Poor Concordance of One-Third Anterior-Posterior Chest Diameter Measurements With Absolute Age-Specific Chest Compression Depth Targets in Pediatric Cardiac Arrest Patients.Journal of the American Heart Association · 2023Observational
- Clinician-reported physiologic monitoring of cardiopulmonary resuscitation quality during pediatric in-hospital cardiac arrest: A propensity-weighted cohort study.Resuscitation · 2023Article
- The physiologic response to epinephrine and pediatric cardiopulmonary resuscitation outcomes.Critical care (London, England) · 2023Article
- Improving vasopressor use in cardiac arrest.Critical care (London, England) · 2023Review
- The future of resuscitation.Clinical and experimental emergency medicine · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
aimMost pediatric in-hospital cardiac arrests (IHCAs) occur in ICUs where invasive hemodynamic monitoring is frequently available. Titrating cardiopulmonary resuscitation (CPR) to the hemodynamic response of the individual improves survival in preclinical models of adult cardiac arrest. The objective of this study was to determine if titrating CPR to systolic blood pressure (SBP) and coronary perfusion pressure (CoPP) in a pediatric porcine model of asphyxia-associated ventricular fibrillation (VF) IHCA would improve survival as compared to traditional CPR.
methodsAfter 7min of asphyxia followed by VF, 4-week-old piglets received either hemodynamic-directed CPR (HD-CPR; compression depth titrated to SBP of 90mmHg and vasopressor administration to maintain CoPP ≥20mmHg); or Standard Care (compression depth 1/3 of the anterior-posterior chest diameter and epinephrine every 4min). All animals received CPR for 10min prior to the first defibrillation attempt. CPR was continued for a maximum of 20min. Protocolized intensive care was provided to all surviving animals for 4h. The primary outcome was 4-h survival.
resultsSurvival rate was greater with HD-CPR (12/12) than Standard Care (6/10; p=0.03). CoPP during HD-CPR was higher compared to Standard Care (point estimate +8.1mmHg, CI
conclusionsHemodynamic-directed CPR improves short-term survival compared to standard depth-targeted CPR in a porcine model of pediatric asphyxia-associated VF IHCA.
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