ArticleThe journal of allergy and clinical immunology. In practice
Mouse Sensitization and Exposure Are Associated with Asthma Severity in Urban Children.
Article in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- Comprehensive home environmental intervention did not reduce allergen concentrations or controller medication requirements among children in Baltimore.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Trial
- Indoor Environmental Factors May Modify the Response to Mouse Allergen Reduction Among Mouse-Sensitized and Exposed Children with Persistent Asthma.The journal of allergy and clinical immunology. In practice · 2021Trial
- Characteristics of inner-city children with life-threatening asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Trial
- Associations between in-home environmental exposures and lung function in a safety net population of children with asthma using electronic health records and geospatial data.Annals of epidemiology · 2025Article
- Associations of aeroallergen testing with reduced oral corticosteroid bursts among adults with asthma.The journal of allergy and clinical immunology. Global · 2025Article
- The Impact of the Indoor Environment on Childhood Asthma.Current allergy and asthma reports · 2025Review
- Minimizing Indoor Allergen Exposure: What Works?Current allergy and asthma reports · 2024Review
- Impact of socioeconomic factors on allergic diseases.The Journal of allergy and clinical immunology · 2024Review
- Factors associated with aeroallergen testing among adults with asthma in a large health system.The journal of allergy and clinical immunology. Global · 2023Article
- Indoor Environmental Exposures and Their Relationship to Allergic Diseases.The journal of allergy and clinical immunology. In practice · 2023Article
- Effects of Allergen Exposure and Environmental Risk Factors in Schools on Childhood Asthma.Current allergy and asthma reports · 2023Review
- Environmental justice and allergic disease: A Work Group Report of the AAAAI Environmental Exposure and Respiratory Health Committee and the Diversity, Equity and Inclusion Committee.The Journal of allergy and clinical immunology · 2023Article
- Allergic rhinitis co-morbidity on asthma outcomes in city school children.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Article
- The role of environmental allergen control in the management of asthma.The World Allergy Organization journal · 2022Review
- Home Dust Allergen Exposure Is Associated with Outcomes among Sensitized Individuals with Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2022Observational
- Allergen Management in Children with Type 2-High Asthma.Journal of asthma and allergy · 2022Review
- Predictors of successful mouse allergen reduction in inner-city homes of children with asthma.The journal of allergy and clinical immunology. In practice · 2021Article
- The Indoor Environment and Childhood Asthma.Current allergy and asthma reports · 2020Review
- Childhood Origins of Adult Lung Disease as Opportunities for Prevention.The journal of allergy and clinical immunology. In practice · 2020Article
- Do Baseline Asthma and Allergic Sensitization Characteristics Predict Responsiveness to Mouse Allergen Reduction?The journal of allergy and clinical immunology. In practice · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundMouse sensitization and exposure are associated with uncontrolled asthma, but whether they are associated with asthma severity, an intrinsic disease characteristic and long-term outcome predictor, is unclear.
objectiveTo examine relationships between mouse sensitization and/or exposure and asthma severity in urban children.
methodsA total of 645 children (5-17 years) with uncontrolled asthma underwent mouse sensitization evaluation. Sensitized children had mouse allergen measured in bedroom dust. Relationships between mouse sensitization, allergen levels, and asthma severity measures (treatment step and Composite Asthma Severity Index [CASI]) were examined using regression models adjusted for age, sex, atopy, study site, race, ethnicity, and insurance.
resultsThe study population was predominantly minority (69.6% black, 20.8% Hispanic), low income (61.8%), and mouse sensitized (54.4%). Mean ± SD treatment step was 3.2 ± 1.6, equivalent to medium-dose inhaled corticosteroid. Mean ± SD CASI was 6.5 ± 3.4, reflecting moderate persistent asthma. Mouse sensitization was associated with higher treatment step (3.5 vs 2.9, mouse-sensitized vs nonsensitized, P < .001), independent of potential confounders (β [95% CI], 0.36 [0.07-0.64]; P = .01). Mouse sensitization was associated independently with CASI (β [95% CI], 0.82 [0.16-1.47]; P = .02). Among mouse-sensitized participants, higher bedroom floor and bed Mus m 1 were independently associated with treatment step (β [95% CI], 0.26 [0.09-0.43]; P = .002 and β [95% CI], 0.22 [0.01-0.43]; P = .04), respectively. Higher bedroom floor Mus m 1 was independently associated with CASI (β [95% CI], 0.43 [0.05-0.81]; P = .03).
conclusionsMouse sensitization and exposure are associated with asthma severity, among low-income, minority children. Further studies are needed to determine whether reducing allergen exposure among mouse-sensitized patients with asthma can reduce severity, ultimately altering childhood asthma natural history.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.