ArticleJournal of affective disorders2017
Neural correlates of RDoC reward constructs in adolescents with diverse psychiatric symptoms: A Reward Flanker Task pilot study.
Article in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Abnormal prediction error processing in schizophrenia and depression.Human brain mapping · 2021Pooled it
- Neural response to reward uncertainty in adolescents with mood and anxiety symptoms.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Altered reward-related resting-state network properties in adolescent cannabis use and depression.Progress in neuro-psychopharmacology & biological psychiatry · 2026Article
- Social support mediates the effects of childhood unpredictability on anhedonia: A retrospective investigation in an online adult community sample.Journal of mood and anxiety disorders · 2024Article
- The Relationship between Neurobiological Function and Inflammation in Depressed Children and Adolescents: A Scoping Review.Neuropsychobiology · 2024Article
- Associations between mother's depressive symptoms during pregnancy and newborn's brain functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Aberrant interhemispheric functional connectivity in major depressive disorder with and without anhedonia.BMC psychiatry · 2022Article
- Neural function underlying reward expectancy and attainment in adolescents with diverse psychiatric symptoms.NeuroImage. Clinical · 2022Article
- Phenotypic and genetic associations between anhedonia and brain structure in UK Biobank.Translational psychiatry · 2021Article
- Altered markers of stress in depressed adolescents after acute social media use.Journal of psychiatric research · 2021Article
- Multimodal Investigations of Reward Circuitry and Anhedonia in Adolescent Depression.Frontiers in psychiatry · 2021Review
- Diminished Feedback Evaluation and Knowledge Updating Underlying Age-Related Differences in Choice Behavior During Feedback Learning.Frontiers in human neuroscience · 2021Article
- Correlates of C-reactive protein with neural reward circuitry in adolescents with psychiatric symptoms.Brain, behavior, & immunity - health · 2020Article
- Neural and behavioral correlates of inhibitory control in youths with varying levels of irritability.Journal of affective disorders · 2020Article
- Anhedonia as a clinical correlate of inflammation in adolescents across psychiatric conditions.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2019Article
- Relationships between neural activation during a reward task and peripheral cytokine levels in youth with diverse psychiatric symptoms.Brain, behavior, and immunity · 2019Article
- Boys with conduct problems and callous-unemotional traits: Neural response to reward and punishment and associations with treatment response.Developmental cognitive neuroscience · 2018Article
- Chronic Stress in Adolescents and Its Neurobiological and Psychopathological Consequences: An RDoC Perspective.Chronic stress (Thousand Oaks, Calif.)Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThere has been growing interest under the Research Domain Criteria initiative to investigate behavioral constructs and their underlying neural circuitry. Abnormalities in reward processes are salient across psychiatric conditions and may precede future psychopathology in youth. However, the neural circuitry underlying such deficits has not been well defined. Therefore, in this pilot, we studied youth with diverse psychiatric symptoms and examined the neural underpinnings of reward anticipation, attainment, and positive prediction error (PPE, unexpected reward gain). Clinically, we focused on anhedonia, known to reflect deficits in reward function.
methodsTwenty-two psychotropic medication-free youth, 16 with psychiatric symptoms, exhibiting a full range of anhedonia, were scanned during the Reward Flanker Task. Anhedonia severity was quantified using the Snaith-Hamilton Pleasure Scale. Functional magnetic resonance imaging analyses were false discovery rate corrected for multiple comparisons.
resultsAnticipation activated a broad network, including the medial frontal cortex and ventral striatum, while attainment activated memory and emotion-related regions such as the hippocampus and parahippocampal gyrus, but not the ventral striatum. PPE activated a right-dominant fronto-temporo-parietal network. Anhedonia was only correlated with activation of the right angular gyrus during anticipation and the left precuneus during PPE at an uncorrected threshold. LIMITATIONS: Findings are preliminary due to the small sample size.
conclusionsThis pilot characterized the neural circuitry underlying different aspects of reward processing in youth with diverse psychiatric symptoms. These results highlight the complexity of the neural circuitry underlying reward anticipation, attainment, and PPE. Furthermore, this study underscores the importance of RDoC research in youth.
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