Evidence map›Paper›PMID 27923454›Full record

ReviewBest practice & research. Clinical endocrinology & metabolism2016

MicroRNAs in the thyroid.

Myriem Boufraqech, Joanna Klubo-Gwiezdzinska, Electron Kebebew

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Best practice & research. Clinical endocrinology & metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04285476 (Study of the Predictive Value of a Signature of microRNA in Thyroid Cytologies of Undetermined Type), which is not on this map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04285476 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

Study of the Predictive Value of a Signature of microRNA in Thyroid Cytologies of Undetermined Type

TypeinterventionalSponsorInstitut du Cancer de Montpellier - Val d'AurelleRan2021 to 2026Enrolled71ConditionsThyroid CancerArmsSignature of microRNA for patients with bethesda classification 3, 4 or 5
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
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  16. Article
  17. Contemporary Thyroid Nodule Evaluation and Management.The Journal of clinical endocrinology and metabolism · 2020
    Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Myriem BoufraqechEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Joanna Klubo-GwiezdzinskaMetabolic Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Electron KebebewEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: kebebewe@mail.nih.gov.
National Institutes of Health · USNational Cancer Institute · US

Funding

Therapeutic targets and novel anticancer agents for endocrine cancersZIABC011286 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NILUBOL, NARIS · 2010 to 2025
$16.6M
Genomic and genetic studies of endocrine cancersZIABC011275 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KEBEBEW, ELECTRON · 2010 to 2018
$8.2M
Application of molecular diagnostics in thyroid cancerZIADK075139 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KLUBO-GWIEZDZINSKA, JOANNA · 2017 to 2025
$4.4M
Studies of Benign and Malignant Thyroid DiseaseZIEDK047053 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KLUBO-GWIEZDZINSKA, JOANNA · 2013 to 2020
$1.9M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA BC011275Intramural NIH HHS ZIA BC011286
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small non-coding RNA comprising approximately 19-25 nucleotides. miRNAs can act as tumour suppressors or oncogenes, and aberrant expression of miRNAs has been reported in several human cancers and has been associated with cancer initiation and progression. Recent evidence suggests that miRNAs play a major role in thyroid carcinogenesis. In this review, we summarize the role of miRNAs in thyroid cancer and describe the oncogenic or tumour suppressor function of miRNAs as well as their clinical utility as prognostic or diagnostic markers in thyroid cancer.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsBiomarkers, TumorHumansMicroRNAsThyroid NeoplasmsBiomarkers, TumorMicroRNAscirculating microRNAdiagnosismicroRNAprognosisthyroid cancertreatment

Identifiers

PMID27923454
PMCPMC5147609
OpenAlexW2546539921

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.