Evidence map›Paper›PMID 27923415›Full record

ArticleActa neuropsychiatrica2017

Association of body mass index-related single nucleotide polymorphisms with psychiatric disease and memory performance in a Japanese population.

Midori Ninomiya-Baba, Junko Matsuo, Daimei Sasayama, Hiroaki Hori, Toshiya Teraishi, Miho Ota, Kotaro Hattori, Takamasa Noda, Ikki Ishida, Shigenobu Shibata and 1 more

Registry-linked trialAbstract read
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In one paragraph

Article in Acta neuropsychiatrica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07654179 (Efficacy of Metformin With Antidepressant Medication as Adjunct Therapy in Depression-obesity Ccomorbidity and Ssociation With NEGR1/RPL31P12 Variants Based on Genotyping), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07654179 narecruitingstarted 2026, after this paper: background citation

Efficacy of Metformin With Antidepressant Medication as Adjunct Therapy in Depression-obesity Ccomorbidity and Ssociation With NEGR1/RPL31P12 Variants Based on Genotyping

Ran2026Enrolled200Registered outcomes10Posted comparisons0ConditionsDepression, Depressive Disorder, Depressive Symptoms, Overweight or ObesityArmsAntidepressant Therapy, Metformin
PMID 39894309PMID 41727810PMID 40096719other papers from this trial
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3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Midori Ninomiya-Baba1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
Junko Matsuo1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
Daimei Sasayama1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
Hiroaki Hori1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
Toshiya Teraishi1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
Miho Ota1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
Kotaro Hattori1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
Takamasa Noda4Department of Psychiatry,National Center of Neurology and Psychiatry Hospital,Tokyo,Japan.
Ikki Ishida1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
Shigenobu Shibata2Laboratory of Physiology and Pharmacology,School of Advanced Science and Engineering,Waseda University,Tokyo,Japan.
Hiroshi Kunugi1Department of Mental Disorder Research,National Center of Neurology and Psychiatry,National Institute of Neuroscience,Tokyo,Japan.
National Center of Neurology and Psychiatry · JPWaseda University · JPShinshu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveObesity is a risk factor for psychiatric diseases. Recently, a number of single nucleotide polymorphisms (SNPs) have been shown to be related to body mass index (BMI). In this study, we investigated the association of BMI-related SNPs with psychiatric diseases and one of their endophenotypes, memory performance, in a Japanese population.

methodsThe subjects were 1624 patients with one of three psychiatric diseases (799 patients with major depressive disorder, 594 with schizophrenia, and 231 with bipolar disorder) and 1189 healthy controls. Memory performance was assessed using the Wechsler Memory Scale - Revised (WMS-R). Genomic DNA was prepared from venous blood and used to genotype 23 BMI-related SNPs using the TaqMan 5'-exonuclease allelic discrimination assay. We then analysed the relationships between the SNPs and psychiatric disease and various subscales of the WMS-R.

resultsThree SNPs (rs11142387, rs12597579, and rs6548238) showed significant differences in the genotype or allele frequency between patients with any psychiatric diseases and controls. Furthermore, six SNPs (rs11142387, rs12597579, rs2815752, rs2074356, rs4776970, and rs2287019) showed significant differences in at least one subscale of the WMS-R depending on the genotypes of the healthy controls. Interestingly, rs11142387 near the Kruppel-like factor 9 (KLF9) was significantly associated with psychiatric disease and poor memory function.

conclusionsWe identified three and six BMI-related SNPs associated with psychiatric disease and memory performance, respectively. In particular, carrying the A allele of rs11142387 near KLF9 was found to be associated with psychiatric disease and poor memory performance, which warrants further investigations.

Indexed as

MemoryPolymorphism, Single NucleotideAdultAsian PeopleBipolar DisorderBody Mass IndexFemaleGenetic Predisposition to DiseaseGenotypeHumansJapanMajor Depressive DisorderMaleMental DisordersMiddle AgedNeuropsychological TestsBMImemorypsychiatric disordersSNPWechsler Memory Scale – Revised

Identifiers

PMID27923415
OpenAlexW2559981983

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.