ArticleParasites & vectors2016
Geographical, landscape and host associations of Trypanosoma cruzi DTUs and lineages.
Article in Parasites & vectors, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Genetic diversity and geographical distribution of Trypanosoma cruzi DTUs in Mexico: A Systematic Review.Revista da Sociedade Brasileira de Medicina Tropical · 2026Pooled it
- Bat-associated Trypanosoma diversity, geographic extension of known clades, and predominance of T. cruzi TcIV in a conserved tropical forest of southeastern Mexico.Parasitology research · 2026Article
- Genetic diversity of Trypanosoma cruzi in individuals with chronic Chagas disease in the Northern Minas Gerais and Vale do Jequitinhonha regions, Minas Gerais, Brazil.PLoS neglected tropical diseases · 2025Article
- Reduced Biodiversity is Linked to Higher Triatomine Occupancy: Chagas Disease Implications.EcoHealth · 2025Article
- Immunologic changes in the peripheral blood transcriptome of individuals with early-stage chronic Chagas cardiomyopathy: a cross-sectional study.Lancet regional health. Americas · 2025Article
- Stable colonization of the kissing bug Rhodnius prolixus by Trypanosoma cruzi Y strain.PLoS neglected tropical diseases · 2025Article
- Fighting Strategies Against Chagas' Disease: A Review.Pathogens (Basel, Switzerland) · 2025Review
- Home invasion of triatomines (Hemiptera: Reduviidae) in the urban area of Mato Grosso, Brazil.Revista da Sociedade Brasileira de Medicina Tropical · 2025Article
- Diagnosis of Trypanosoma cruzi infection in Mexican populations: current conventional serology lacks adequate sensitivity and specificity.Memorias do Instituto Oswaldo Cruz · 2025Article
- The epidemiology of Chagas disease in the Americas.Lancet regional health. Americas · 2024Review
- Characterization of NovelInternational journal of molecular sciences · 2024Article
- Fifteen Years after the Definition ofLife (Basel, Switzerland) · 2023Review
- Article
- Clinical use of molecular methods forFrontiers in parasitology · 2023Article
- Animal Models ofPathogens (Basel, Switzerland) · 2022Review
- Chronic Chagas Disease-the Potential Role of Reinfections in Cardiomyopathy Pathogenesis.Current heart failure reports · 2022Review
- Discrete typing units of Trypanosoma cruzi: Geographical and biological distribution in the Americas.Scientific data · 2022Article
- Surveillance and genotype characterization of zoonotic trypanosomatidae inInternational journal for parasitology. Parasites and wildlife · 2022Article
- Presence and potential distribution of malaria-infected New World primates of Costa Rica.Malaria journal · 2022Article
- Trypanosoma cruzi genetic diversity: impact on transmission cycles and Chagas disease.Memorias do Instituto Oswaldo Cruz · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe evolutionary history and ecological associations of Trypanosoma cruzi, the need to identify genetic markers that can distinguish parasite subpopulations, and understanding the parasite's evolutionary and selective processes have been the subject of a significant number of publications since 1998, the year when the first DNA sequence analysis for the species was published.
methodsThe current analysis systematizes and re-analyzes this original research, focusing on critical methodological and analytical variables and results that have given rise to interpretations of putative patterns of genetic diversity and diversification of T. cruzi lineages, discrete typing units (DTUs), and populations, and their associations with hosts, vectors, and geographical distribution that have been interpreted as evidence for parasite subpopulation specificities.
resultsFew studies use hypothesis-driven or quantitative analysis for T. cruzi phylogeny (16/58 studies) or phylogeography (10/13). Among these, only one phylogenetic and five phylogeographic studies analyzed molecular markers directly from tissues (i.e. not from isolates). Analysis of T. cruzi DTU or lineage niche and its geographical projection demonstrate extensive sympatry among all clades across the continent and no significant niche differences among DTUs. DTU beta-diversity was high, indicating diverse host assemblages across regions, while host dissimilarity was principally due to host species turnover and to a much lesser degree to nestedness. DTU-host order specificities appear related to trophic or microenvironmental interactions.
conclusionsMore rigorous study designs and analyses will be required to discern evolutionary processes and the impact of landscape modification on population dynamics and risk for T. cruzi transmission to humans.
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