ArticlePLoS biology2016
Natural Variation in Arabidopsis Cvi-0 Accession Reveals an Important Role of MPK12 in Guard Cell CO2 Signaling.
Article in PLoS biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 84 citations in OpenAlex.
- Guard cell signal transduction mechanisms controlling stomatal movements by light, abscisic acid, CO2, VPD and heat.Plant physiology · 2026Review
- Variance in Calvin-Benson cycle intermediate levels between closely related species in the tomato clade.Journal of experimental botany · 2026Article
- Are PP2Cs with intrinsically disordered regions CO2 sensors that control stomatal movements?Plant physiology · 2026Article
- Stomatal CO2 sensing in plants: control of gas exchange and interactions with environmental stimuli.Plant & cell physiology · 2025Review
- Parallel evolution of salinity tolerance inScience advances · 2025Article
- Identification of the STY13 gene family across the entire genome and an analysis of the essential function of GhSTY13-12 in cotton's response to abiotic stress.Functional & integrative genomics · 2025Article
- TOT3-AHA1 module: its role in fine-tuning stomatal responses.Frontiers in plant science · 2025Review
- GABA does not regulate stomatal CO2 signalling in Arabidopsis.Journal of experimental botany · 2024Article
- Stomatal CO2 responses at sub- and above-ambient CO2 levels employ different pathways in Arabidopsis.Plant physiology · 2024Article
- A network-based modeling framework reveals the core signal transduction network underlying high carbon dioxide-induced stomatal closure in guard cells.PLoS biology · 2024Article
- Stomatal responses to VPD utilize guard cell intracellular signaling components.Frontiers in plant science · 2024Article
- Microtubule-associated protein SlMAP70 interacts with IQ67-domain protein SlIQD21a to regulate fruit shape in tomato.The Plant cell · 2023Article
- MPK12 in stomatal COThe New phytologist · 2023Article
- Genomic Basis of Adaptation to a Novel Precipitation Regime.Molecular biology and evolution · 2023Article
- Burning questions for a warming and changing world: 15 unknowns in plant abiotic stress.The Plant cell · 2023Article
- Stomatal COScience advances · 2022Article
- Starch biosynthesis in guard cells has features of both autotrophic and heterotrophic tissues.Plant physiology · 2022Article
- The maize single-nucleus transcriptome comprehensively describes signaling networks governing movement and development of grass stomata.The Plant cell · 2022Article
- The significance of calcium-sensing receptor in sustaining photosynthesis and ameliorating stress responses in plants.Frontiers in plant science · 2022Review
- Ozone and nitrogen dioxide regulate similar gene expression responses in Arabidopsis but natural variation in the extent of cell death is likely controlled by different genetic loci.Frontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
25 authors at 6 institutions in 6 countries.
Funding
Abstract
Plant gas exchange is regulated by guard cells that form stomatal pores. Stomatal adjustments are crucial for plant survival; they regulate uptake of CO2 for photosynthesis, loss of water, and entrance of air pollutants such as ozone. We mapped ozone hypersensitivity, more open stomata, and stomatal CO2-insensitivity phenotypes of the Arabidopsis thaliana accession Cvi-0 to a single amino acid substitution in MITOGEN-ACTIVATED PROTEIN (MAP) KINASE 12 (MPK12). In parallel, we showed that stomatal CO2-insensitivity phenotypes of a mutant cis (CO2-insensitive) were caused by a deletion of MPK12. Lack of MPK12 impaired bicarbonate-induced activation of S-type anion channels. We demonstrated that MPK12 interacted with the protein kinase HIGH LEAF TEMPERATURE 1 (HT1)-a central node in guard cell CO2 signaling-and that MPK12 functions as an inhibitor of HT1. These data provide a new function for plant MPKs as protein kinase inhibitors and suggest a mechanism through which guard cell CO2 signaling controls plant water management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.