Evidence map›Paper›PMID 27922818›Full record

ArticleAging2016

Age-related changes in the gene expression profile of antigen-specific mouse CD8+ T cells can be partially reversed by blockade of the BTLA/CD160 pathways during vaccination.

Noor Dawany, Elizabeth M Parzych, Louise C Showe, Hildegund Cj Ertl

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Noor DawanyWistar Institute, Philadelphia, PA 19104, USA.
Elizabeth M ParzychWistar Institute, Philadelphia, PA 19104, USA.
Louise C ShoweWistar Institute, Philadelphia, PA 19104, USA.
Hildegund Cj ErtlWistar Institute, Philadelphia, PA 19104, USA.
The Wistar Institute · USChildren's Hospital of Philadelphia · USDrexel University · US

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
NCI NIH HHS P30 CA010815
6 · The paper itself

Abstract

We analyzed gene expression profiles of young and aged mouse CD8

Indexed as

AgingAnimalsAntigens, CDCD8-Positive T-LymphocytesFemaleGene Expression RegulationGPI-Linked ProteinsInfluenza A virusInfluenza VaccinesMiceMice, Inbred C57BLOrthomyxoviridae InfectionsReceptors, ImmunologicTranscriptomeVaccinationAntigens, CDBTLA protein, mouseCd160 protein, mouseGPI-Linked ProteinsInfluenza VaccinesReceptors, ImmunologicagingBTLA/CD160CD8+ cellsgene expressionvaccination

Identifiers

PMID27922818
PMCPMC5270668
OpenAlexW2552771798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.