Evidence map›Paper›PMID 27922636›Full record

ArticleTranslational psychiatry2016

DNA methylation and substance-use risk: a prospective, genome-wide study spanning gestation to adolescence.

C A M Cecil, E Walton, R G Smith, E Viding, E J McCrory, C L Relton, M Suderman, J-B Pingault, W McArdle, T R Gaunt and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04422600 (Fetal Exposure to Cannabinoids), which is not on this map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04422600 completednot on this mapstarted 2020, after this paper: background citation

Fetal Exposure to Cannabinoids: Exposure, Methylation and Neurodevelopmental Effects

Typeobservational_patient_registrySponsorUniversity of ArkansasRan2020 to 2023Enrolled72ConditionsFetal Exposure Timing UnspecifiedArmsThere is no other intervention, only clinical treatment.
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
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  12. Considerations toward an epigenetic and common pathways theory of mental disorder.Journal of psychopathology and clinical science · 2023
    Article
  13. Article
  14. Article
  15. PACSIN proteins in vivo: Roles in development and physiology.Acta physiologica (Oxford, England) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

C A M CecilDepartment of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
E WaltonDepartment of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
R G SmithExeter Medical School, Exeter University, Exeter, UK.
E VidingDivision of Psychology and Language Sciences, Department of Clinical, Educational and Health Psychology, University College London, London, UK.
E J McCroryDivision of Psychology and Language Sciences, Department of Clinical, Educational and Health Psychology, University College London, London, UK.
C L ReltonSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
M SudermanSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
J-B PingaultDivision of Psychology and Language Sciences, Department of Clinical, Educational and Health Psychology, University College London, London, UK.
W McArdleSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
T R GauntSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
J MillExeter Medical School, Exeter University, Exeter, UK.
E D BarkerDepartment of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
University of Bristol · GBKing's College London · GBUniversity College London · GBUniversity of Exeter · GB

Funding

Epigenetic Pathways to Conduct Problem Trajectories: Early Environmental RisksR01HD068437 · NICHD · KING'S COLLEGE LONDON · PI BARKER, EDWARD D., MILL, JONATHAN · 2012 to 2014
$1.1M
Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_UU_12013/2Medical Research Council MC_UU_12013/8NICHD NIH HHS R01 HD068437Wellcome Trust
6 · The paper itself

Abstract

Epigenetic processes have been implicated in addiction; yet, it remains unclear whether these represent a risk factor and/or a consequence of substance use. Here, we believe we conducted the first genome-wide, longitudinal study to investigate whether DNA methylation patterns in early life prospectively associate with substance use in adolescence. The sample comprised of 244 youth (51% female) from the Avon Longitudinal Study of Parents and Children (ALSPAC), with repeated assessments of DNA methylation (Illumina 450k array; cord blood at birth, whole blood at age 7) and substance use (tobacco, alcohol and cannabis use; age 14-18). We found that, at birth, epigenetic variation across a tightly interconnected genetic network (n=65 loci; q<0.05) associated with greater levels of substance use during adolescence, as well as an earlier age of onset amongst users. Associations were specific to the neonatal period and not observed at age 7. Key annotated genes included PACSIN1, NEUROD4 and NTRK2, implicated in neurodevelopmental processes. Several of the identified loci were associated with known methylation quantitative trait loci, and consequently likely to be under significant genetic control. Collectively, these 65 loci were also found to partially mediate the effect of prenatal maternal tobacco smoking on adolescent substance use. Together, findings lend novel insights into epigenetic correlates of substance use, highlight birth as a potentially sensitive window of biological vulnerability and provide preliminary evidence of an indirect epigenetic pathway linking prenatal tobacco exposure and adolescent substance use.

Indexed as

DNA MethylationAdolescentAlcohol DrinkingChildChild, PreschoolEpigenesis, GeneticFemaleGenome, HumanGenome-Wide Association StudyHumansInfantInfant, NewbornLongitudinal StudiesMaleMarijuana AbuseNerve Tissue ProteinsNerve Tissue Proteins

Identifiers

PMID27922636
PMCPMC5315565
OpenAlexW2560585971

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.