ArticleSpinal cord2017
Molecular mechanisms underlying the positive role of treadmill training in locomotor recovery after spinal cord injury.
Article in Spinal cord, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Osteopontin enhances the effect of treadmill training and promotes functional recovery after spinal cord injury.Molecular biomedicine · 2023Article
- Identification of the potential regulatory interactions in rheumatoid arthritis through a comprehensive analysis of lncRNA-related ceRNA networks.BMC musculoskeletal disorders · 2023Article
- Gene expression and locomotor recovery in adult rats with spinal cord injury and plasma-synthesized polypyrrole/iodine application combined with a mixed rehabilitation scheme.Frontiers in neurology · 2023Article
- A Bioinformatics Study of Differentially Expressed Genes in Microarrays of Dorsal Root Ganglia from Rat Models of Neuropathic Pain.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Article
- Bioinformatics analysis of the wheel treadmill test on motor function recovery after spinal cord injury.Ibrain · 2021Article
- MAP‑1B, PACS‑2 and AHCYL1 are regulated by miR‑34A/B/C and miR‑449 in neuroplasticity following traumatic spinal cord injury in rats: Preliminary explorative results from microarray data.Molecular medicine reports · 2019Article
- Activity-Based Physical Rehabilitation with Adjuvant Testosterone to Promote Neuromuscular Recovery after Spinal Cord Injury.International journal of molecular sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to investigate the molecular mechanisms underlying the positive role of treadmill training (TMT) in locomotor recovery.
methodsGSE52763 microarray data were downloaded from GEO database, which was collected from the lumbar spinal cord samples of three groups of mice: mice subjected to contusive injury and killed 1 week after injury (I1), mice subjected to injury and killed 3 weeks after injury (I3), and mice subjected to injury and TMT beginning at week 1 and lasting until week 3 (T3). Differential expression analysis between I3 and I1, between T3 and I1 and between T3 and I3 were performed by T-test using R/LIMMA. Genes with |log
resultsFinally, 82 upregulated DEGs and 297 downregulated DEGs were found specifically induced by TMT. Specific upregulated DEGs were mostly enriched in response to organic substance and morphogenesis-related events, and specific downregulated DEGs were related to positive regulation of transcription. ATP2A1, PRKACA, ITPR2 and so on had high connection degree in the PPI network of the specific upregulated DEGs; FOS, GSK3B and so on had high degrees in the PPI network of the specific downregulated DEGs.
conclusionATP2A1, C-FOS and GSK3B may have critical roles in the positive role of TMT in locomotor recovery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.