Evidence map›Paper›PMID 27922594›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017

Cacna1c in the Prefrontal Cortex Regulates Depression-Related Behaviors via REDD1.

Zeeba D Kabir, Anni S Lee, Caitlin E Burgdorf, Delaney K Fischer, Aditi M Rajadhyaksha, Florence Lee, Bryant Rizzo, Richard C Rice, Kamalpreet Singh, Kristie T Ota and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Astrocytic abnormalities in brain-specificChannels (Austin, Tex.) · 2025
    Article
  4. The Impact of Overexpression of the Mouse Ortholog ofBiological psychiatry global open science · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. L-methionine and the L-type CaFrontiers in neural circuits · 2024
    Article
  10. Review
  11. Article
  12. Neuronal deletion of CaScientific reports · 2022
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Mutations in DISC1 alter IPNeuronal signaling · 2021
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Zeeba D KabirDivision of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Anni S LeeDivision of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Caitlin E BurgdorfDivision of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Delaney K FischerDivision of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Aditi M RajadhyakshaDivision of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Florence LeeDivision of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Bryant RizzoDivision of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Richard C RiceDivision of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Kamalpreet SinghDivision of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Kristie T OtaLaboratory of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Danielle M GerhardLaboratory of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Kathryn C SchierberlDivision of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Michael J GlassFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Ronald S DumanLaboratory of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Anjali M RajadhyakshaDivision of Pediatric Neurology, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Weill Cornell Medicine · USCornell University · USMIND Research Institute · USYale University · US

Funding

The Role of Cav1.2 L-type Ca2+ Channels in Cocaine-Induced ReinstatementR01DA029122 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI RAJADHYAKSHA, ANJALI M · 2012 to 2016
$2.1M
Genetic and Environmental Influences on AddictionT32DA039080 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI Teresa A Milner · 2017 to 2026
$1.4M
NIDA NIH HHS R01 DA029122NIDA NIH HHS T32 DA039080
6 · The paper itself

Abstract

The CACNA1C gene that encodes the L-type Ca

Indexed as

AnhedoniaAnimalsBrain-Derived Neurotrophic FactorCalcium Channels, L-TypeDepressive DisorderDietary SucroseDisease Models, AnimalFeeding BehaviorForkhead Box Protein O3Gene Knockdown TechniquesMice, Inbred C57BLMice, TransgenicMotor ActivityPhosphorylationPrefrontal CortexProto-Oncogene Proteins c-aktBrain-Derived Neurotrophic FactorCACNA1C protein, mouseCalcium Channels, L-TypeDdit4 protein, mouseDietary SucroseForkhead Box Protein O3FoxO3 protein, mousemTOR protein, mouseProto-Oncogene Proteins c-aktRNA, MessengerTOR Serine-Threonine KinasesTranscription Factors

Identifiers

PMID27922594
PMCPMC5561335
OpenAlexW2560159796

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.