ArticleScientific reports2016
Elderly patients have an altered gut-brain axis regardless of the presence of cirrhosis.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review.Clinical interventions in aging · 2018Pooled it
- Establishment and validation of a prognosis nomogram for MIMIC-III patients with liver cirrhosis complicated with hepatic encephalopathy.BMC gastroenterology · 2023Trial
- Identification of enterotype for patients with Alzheimer's disease.Journal of translational medicine · 2025Article
- Disease- and stage-specific alterations of the oral and fecal microbiota in Alzheimer's disease.PNAS nexus · 2024Article
- Specific Challenges in Geriatric Cirrhosis and Hepatic Encephalopathy.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022Review
- Article
- A prospective investigation into the association between the gut microbiome composition and cognitive performance among healthy young adults.Gut pathogens · 2022Article
- Fixing Functional GI Disorders Using Microbes: Easier Said Than Done.Frontiers in endocrinology · 2022Article
- Emerging Evidence on the Use of Probiotics and Prebiotics to Improve the Gut Microbiota of Older Adults with Frailty Syndrome: A Narrative Review.The journal of nutrition, health & aging · 2022Review
- Nicotinamide adenine dinucleotide supplementation drives gut microbiota variation in Alzheimer's mouse model.Frontiers in aging neuroscience · 2022Article
- Enhancing the Cognitive Effects of Flavonoids With Physical Activity: Is There a Case for the Gut Microbiome?Frontiers in neuroscience · 2022Review
- Effect of Nutrition on Age-Related Metabolic Markers and the Gut Microbiota in Cats.Microorganisms · 2021Article
- The emerging role of probiotics in neurodegenerative diseases: new hope for Parkinson's disease?Neural regeneration research · 2021Article
- Gut microbiota signatures in Schistosoma japonicum infection-induced liver cirrhosis patients: a case-control study.Infectious diseases of poverty · 2021Article
- Association between serum albumin and cognitive dysfunction in hepatic encephalopathy: An exploratory data analysis.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Gut microbiota interacts with intrinsic brain activity of patients with amnestic mild cognitive impairment.CNS neuroscience & therapeutics · 2021Article
- Chronic Liver Diseases and the Microbiome-Translating Our Knowledge of Gut Microbiota to Management of Chronic Liver Disease.Gastroenterology · 2021Review
- Gut Microbiota: Critical Controller and Intervention Target in Brain Aging and Cognitive Impairment.Frontiers in aging neuroscience · 2021Review
- Minimal Hepatic Encephalopathy and Mild Cognitive Impairment Worsen Quality of Life in Elderly Patients With Cirrhosis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2020Article
- Associations between gut microbiota and Alzheimer's disease, major depressive disorder, and schizophrenia.Journal of neuroinflammation · 2020Article
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20 authors.
Funding
Abstract
Cognitive difficulties manifested by the growing elderly population with cirrhosis could be amnestic (memory-related) or non-amnestic (memory-unrelated). The underlying neuro-biological and gut-brain changes are unclear in this population. We aimed to define gut-brain axis alterations in elderly cirrhotics compared to non-cirrhotic individuals based on presence of cirrhosis and on neuropsychological performance. Age-matched outpatients with/without cirrhosis underwent cognitive testing (amnestic/non-amnestic domains), quality of life (HRQOL), multi-modal MRI (fMRI go/no-go task, volumetry and MR spectroscopy), blood (inflammatory cytokines) and stool collection (for microbiota). Groups were studied based on cirrhosis/not and also based on neuropsychological performance (amnestic-type, amnestic/non-amnestic-type and unimpaired). Cirrhotics were impaired on non-amnestic and selected amnestic tests, HRQOL and systemic inflammation compared to non-cirrhotics. Cirrhotics demonstrated significant changes on MR spectroscopy but not on fMRI or volumetry. Correlation networks showed that Lactobacillales members were positively while Enterobacteriaceae and Porphyromonadaceae were negatively linked with cognition. Using the neuropsychological classification amnestic/non-amnestic-type individuals were majority cirrhosis and had worse HRQOL, higher inflammation and decreased autochthonous taxa relative abundance compared to the rest. This classification also predicted fMRI, MR spectroscopy and volumetry changes between groups. We conclude that gut-brain axis alterations may be associated with the type of neurobehavioral decline or inflamm-aging in elderly cirrhotic subjects.
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