Evidence map›Paper›PMID 27922067›Full record

ArticleScientific reports2016

Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 Infection.

Weihui Fu, Chao Qiu, Mingzhe Zhou, Lingyan Zhu, Yu Yang, Chenli Qiu, Linxia Zhang, Xuan Xu, Ying Wang, Jianqing Xu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Weihui FuShanghai Public Health Clinical Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Chao QiuShanghai Public Health Clinical Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Mingzhe ZhouShanghai Public Health Clinical Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Lingyan ZhuKey Laboratory of Medical Molecular Virology of Ministry of Education/Health at Shanghai Medical College, Fudan University, Shanghai, China.
Yu YangKey Laboratory of Medical Molecular Virology of Ministry of Education/Health at Shanghai Medical College, Fudan University, Shanghai, China.
Chenli QiuKey Laboratory of Medical Molecular Virology of Ministry of Education/Health at Shanghai Medical College, Fudan University, Shanghai, China.
Linxia ZhangKey Laboratory of Medical Molecular Virology of Ministry of Education/Health at Shanghai Medical College, Fudan University, Shanghai, China.
Xuan XuKey Laboratory of Medical Molecular Virology of Ministry of Education/Health at Shanghai Medical College, Fudan University, Shanghai, China.
Ying WangShanghai Municipal Center for Disease Control &Prevention, Shanghai, China.
Jianqing XuShanghai Public Health Clinical Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Xiaoyan ZhangShanghai Public Health Clinical Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
Shanghai Medical College of Fudan University · CNHuashan Hospital · CNShanghai Municipal Center For Disease Control Prevention · CNShanghai Public Health Clinical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SAMHD1 restricts human immunodeficiency virus type 1 (HIV-1) replication in myeloid cells and CD4

Indexed as

AdultAgedAnti-HIV AgentsCell LineChronic DiseaseFemaleHIV-1HIV InfectionsHost-Pathogen InteractionsHumansInterferon-gammaMaleMiddle AgedProteolysisSAM Domain and HD Domain-Containing Protein 1Viral LoadAnti-HIV AgentsInterferon-gammaSAM Domain and HD Domain-Containing Protein 1SAMHD1 protein, humanViral Regulatory and Accessory ProteinsVPX protein, Simian immunodeficiency virus

Identifiers

PMID27922067
PMCPMC5138643
OpenAlexW2560678901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.