Evidence map›Paper›PMID 27921242›Full record

ArticleMolecular neurobiology2017

Human Mesenchymal Stem Cells from Adipose Tissue Differentiated into Neuronal or Glial Phenotype Express Different Aquaporins.

Rosanna Avola, Adriana Carol Eleonora Graziano, Giovanna Pannuzzo, Venera Cardile

RetractedAbstract readRetracted Publication
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Molecules (Basel, Switzerland) · 2018
    Article
  10. Physiologically based microenvironment forWorld journal of stem cells · 2018
    Review
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Rosanna AvolaDepartment of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, Via Santa Sofia 89, 95125, Catania, Italy.
Adriana Carol Eleonora GrazianoDepartment of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, Via Santa Sofia 89, 95125, Catania, Italy.
Giovanna PannuzzoDepartment of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, Via Santa Sofia 89, 95125, Catania, Italy.
Venera CardileDepartment of Biomedical and Biotechnological Sciences, Section of Physiology, University of Catania, Via Santa Sofia 89, 95125, Catania, Italy. cardile@unict.it.
University of Catania · IT

Funding

Ricerca Finanziata Ateneo (University of Catania) Cod. 21040104
6 · The paper itself

Abstract

Aquaporins (AQPs) are 13 integral membrane proteins that provide selective pores for the rapid movement of water and other uncharged solutes, across cell membranes. Recently, AQPs have been focused for their role in production, circulation, and homeostasis of the cerebrospinal fluid and their importance in several human diseases is becoming clear. This study investigated the time course (0, 14, and 28 days) of AQP1, 4, 7, 8, and 9 during the neural differentiation of human mesenchymal stem cells (MSCs) from adipose tissue (AT). For this purpose, two different media, enriched with serum or B-27 and N1 supplements, were applied to give a stimulus toward neural lineage. After 14 days, the cells were cultured with neuronal or glial differentiating medium for further 14 days. The results confirmed that AT-MSCs could be differentiated into neurons, astrocytes, and oligodendrocytes, expressing not only the typical neural markers but also specific AQPs depending on differentiated cell type. Our data demonstrated that at 28 days, AT-MSCs express only AQP1; astrocytes AQP1, 4, and 7; oligodendrocytes AQP1, 4, and 8; and finally neurons AQP1 and 7. This study provides fundamental insight into the biology of the mesenchymal stem cells and it suggests that AQPs can be potential neural markers.

Indexed as

Adipose TissueAdultAquaporinsCell DifferentiationCells, CulturedFemaleGene ExpressionHumansMaleMesenchymal Stem CellsNeurogliaNeuronsPhenotypeYoung AdultAquaporinsAQPsAstrocyteCell cultureNeural differentiationNeuronOligodendrocyte

Identifiers

PMID27921242
OpenAlexW2559288145

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.