Trial reportCognitive, affective & behavioral neuroscience2017
Neural correlates of rumination in adolescents with remitted major depressive disorder and healthy controls.
Trial report in Cognitive, affective & behavioral neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03859297 (Developing Rumination-focused Treatment to Reduce Risk for Depression Recurrence), which is not on this map. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Developing Rumination-focused Treatment to Reduce Risk for Depression Recurrence (RDR) in Adolescence
Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- Neuroimaging insights into the psychosocial impact of the COVID-19 pandemic: a systematic review.Translational psychiatry · 2025Pooled it
- Rumination induction task in fMRI: Effects of rumination focused cognitive behavioral therapy and stability in youth.Journal of affective disorders · 2025Trial
- Effects of a randomised trial of 5-week heart rate variability biofeedback intervention on mind wandering and associated brain function.Cognitive, affective & behavioral neuroscience · 2022Trial
- Psychometric Properties of the Chinese Version of the Brief State Rumination Inventory.Frontiers in public health · 2022Trial
- Trial
- Sadness regulation in daily life in remitted depression: Regulatory repertoire composition and affect-dependent effectiveness.Journal of affective disorders · 2026Article
- Characterizing gradients of functional connectome underpinning rumination and their alteration in depression.Translational psychiatry · 2026Article
- The effects of rumination and reappraisal on repeated exposure to stress.Comprehensive psychoneuroendocrinology · 2026Article
- High-gamma tACS may regulate brain network connectivity to alleviate symptoms in female adolescent non-suicidal self-injury: a preliminary TMS-EEG pilot study.BMC psychiatry · 2026Article
- Consistent Brain Entropy Changes During Rumination Across Three Magnetic Resonance Imaging Scanners.Neural plasticity · 2026Article
- Shared but distinct functional connectome profiles underlying rumination in depressed and healthy individuals.BMC psychiatry · 2025Article
- Article
- Evidence of Disrupted Hippocampal Gray- and White-Matter Development in Adolescent Anxiety Disorders, Independent From Early-Life Stress.Hippocampus · 2025Article
- Neural Electrical Correlates of Subjective Happiness.Human brain mapping · 2025Article
- Rumination and drug craving scores in Chinese male patients with methamphetamine and heroin use disorders: a cross-sectional study.Substance abuse treatment, prevention, and policy · 2025Article
- Dynamic functional connectivity signatures of focused attention on the breath in adolescents.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Neural activity during negative self-evaluation is associated with negative self-concept and depressive symptoms in adolescent girls.Development and psychopathology · 2025Article
- An investigation of the interaction of trait repetitive negative thinking and neuroticism on brain activity during negative self-referential processing: a cross-sectional fMRI study.Social cognitive and affective neuroscience · 2025Article
- Article
- Brain mechanisms of rumination and negative self-referential processing in adolescent depression.Journal of affective disorders · 2024Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The aim of the present study was to use fMRI to examine the neural correlates of engaging in rumination among a sample of remitted depressed adolescents, a population at high risk for future depressive relapse. A rumination induction task was used to assess differences in the patterns of neural activation during rumination versus a distraction condition among 26 adolescents in remission from major depressive disorder (rMDD) and in 15 healthy control adolescents. Self-report depression and rumination, as well as clinician-rated depression, were also assessed among all participants. All of the participants recruited regions in the default mode network (DMN), including the posterior cingulate cortex, medial prefrontal cortex, inferior parietal lobe, and medial temporal gyrus, during rumination. Increased activation in these regions during rumination was correlated with increased self-report rumination and symptoms of depression across all participants. Adolescents with rMDD also exhibited greater activation in regions involved in visual, somatosensory, and emotion processing than did healthy peers. The present findings suggest that during ruminative thought, adolescents with rMDD are characterized by increased recruitment of regions within the DMN and in areas involved in visual, somatosensory, and emotion processing.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.