Evidence map›Paper›PMID 27921147›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017

Can the alendronate dosage be altered when combined with high-frequency loading in osteoporosis treatment?

C B Correa, G V Camargos, M Chatterjee, M F Mesquita, A A Del Bel Cury, I Naert, J Duyck, K Vandamme

Abstract read
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In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

C B CorreaDepartment of Oral Health Sciences & Dental Clinic, BIOMAT & Prosthetic Dentistry, KU Leuven & University Hospitals Leuven, Kapucijnenvoer 7, 3000, Leuven, Belgium.
G V CamargosDepartment of Oral Health Sciences & Dental Clinic, BIOMAT & Prosthetic Dentistry, KU Leuven & University Hospitals Leuven, Kapucijnenvoer 7, 3000, Leuven, Belgium.
M ChatterjeeDepartment of Oral Health Sciences & Dental Clinic, BIOMAT & Prosthetic Dentistry, KU Leuven & University Hospitals Leuven, Kapucijnenvoer 7, 3000, Leuven, Belgium.
M F MesquitaDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
A A Del Bel CuryDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
I NaertDepartment of Oral Health Sciences & Dental Clinic, BIOMAT & Prosthetic Dentistry, KU Leuven & University Hospitals Leuven, Kapucijnenvoer 7, 3000, Leuven, Belgium.
J DuyckDepartment of Oral Health Sciences & Dental Clinic, BIOMAT & Prosthetic Dentistry, KU Leuven & University Hospitals Leuven, Kapucijnenvoer 7, 3000, Leuven, Belgium.
K VandammeDepartment of Oral Health Sciences & Dental Clinic, BIOMAT & Prosthetic Dentistry, KU Leuven & University Hospitals Leuven, Kapucijnenvoer 7, 3000, Leuven, Belgium. Katleen.Vandamme@med.kuleuven.be.
KU Leuven · BEUniversidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de Alfenas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alendronate therapy has been associated with serious side effects. Altering the alendronate concentration and combining with high-frequency loading as mechanical intervention was explored in this animal study as a treatment for osteoporosis. The bone anabolic potency of high-frequency loading was overruled by the different alendronate dosages applied in the present study. Further exploration of reduced hormonal therapy associated with mechanical interventions in osteoporosis treatment should be sought.

introductionThe aim of the present study was to investigate the effect of alendronate (ALN) administration at two different dosages, associated or not with high-frequency (HF) loading, on the bone microstructural response.

methodsSixty-four female Wistar rats were used, of which 48 were ovariectomized (OVX) and 16 were sham-operated (shOVX). The OVX animals were divided into three groups: two groups were treated with alendronate, at a dosage of 2 mg/kg (ALN(

resultsTrabecular bone loss and structural deterioration resulting from ovariectomy were partially restored by ALN administration, demonstrated by the improvement of trabecular patter factor (Tb.Pf), trabecular separation (Tb.Sp), and structure model index (SMI) of the ALN groups compared to that of the OVX group, regardless of the applied dosage [ALN(

conclusionsThe bone anabolic potency of HF loading was overruled by the ALN dosages applied in the present study. Further altering the ALN dosage combined with robust mechanical stimuli needs to be considered in osteoporosis research and eventually therapy.

Indexed as

AlendronateAnimalsBone DensityBone Density Conservation AgentsCombined Modality TherapyDose-Response Relationship, DrugFemaleOsteoporosisOvariectomyRats, WistarTibiaVibrationWeight-BearingX-Ray MicrotomographyAlendronateBone Density Conservation AgentsBisphosphonates dosagesBone microarchitectureHigh-frequency loadingOvariectomy

Identifiers

PMID27921147
OpenAlexW2560026254

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.