ArticleImmunogenetics2017
The genetic architecture of the MHC class II region in British Texel sheep.
Article in Immunogenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- IMAGE001: A new livestock multispecies SNP array to characterize genomic variation in European livestock gene bank collections.Animal genetics · 2025Article
- MHC class IIa haplotypes derived by high-throughput SNP screening in an isolated sheep population.G3 (Bethesda, Md.) · 2021Article
- Characterisation of major histocompatibility complex class IIa haplotypes in an island sheep population.Immunogenetics · 2019Article
- Allelic nomenclature for the duplicated MHC class II DQ genes in sheep.Immunogenetics · 2019Article
- Structural and functional diversity arising from intra- and inter-haplotype combinations of duplicated DQA and B loci within the ovine MHC.Immunogenetics · 2018Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 7 countries.
Funding
Abstract
Understanding the structure of the major histocompatibility complex, especially the number and frequency of alleles, loci and haplotypes, is crucial for efficient investigation of the way in which the MHC influences susceptibility to disease. Nematode infection is one of the most important diseases suffered by sheep, and the class II region has been repeatedly associated with differences in susceptibility and resistance to infection. Texel sheep are widely used in many different countries and are relatively resistant to infection. This study determined the number and frequency of MHC class II genes in a small flock of Texel sheep. There were 18 alleles at DRB1, 9 alleles at DQA1, 13 alleles at DQB1, 8 alleles at DQA2 and 16 alleles at DQB2. Several haplotypes had no detectable gene products at DQA1, DQB1 or DQB2, and these were defined as null alleles. Despite the large numbers of alleles, there were only 21 distinct haplotypes in the population. The relatively small number of observed haplotypes will simplify finding disease associations because common haplotypes provide more statistical power but complicate the discrimination of causative mutations from linked marker loci.
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Registered trials
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