ArticlePsychopharmacology2017
Cocaine administration dose-dependently increases sexual desire and decreases condom use likelihood: The role of delay and probability discounting in connecting cocaine with HIV.
Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 6 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- A systematic review and meta-analysis of test-retest reliability and stability of delay and probability discounting.Journal of the experimental analysis of behavior · 2024Pooled it
- Measuring Sexual Risk-Taking: A Systematic Review of the Sexual Delay Discounting Task.Archives of sexual behavior · 2022Pooled it
- Sexual discounting: A systematic review of discounting processes and sexual behavior.Experimental and clinical psychopharmacology · 2021Pooled it
- A systematic review and meta-analysis of delay discounting and cannabis use.Experimental and clinical psychopharmacology · 2021Pooled it
- Relationships among impulsive, addictive and sexual tendencies and behaviours: a systematic review of experimental and prospective studies in humans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Pooled it
- Does being drunk or high cause HIV sexual risk behavior? A systematic review of drug administration studies.Pharmacology, biochemistry, and behavior · 2018Pooled it
- Polysubstance use patterns and risk behaviors among people with cocaine use disorder.Experimental and clinical psychopharmacology · 2025Trial
- The Blinded-Dose Purchase Task: assessing hypothetical demand based on cocaine, methamphetamine, and alcohol administration.Psychopharmacology · 2023Trial
- Prevalence of HIV and Hepatitis C and access to opioid substitution treatment among people who inject drugs in three cities in Croatia: findings from the second wave of respondent-driven sampling surveys.Harm reduction journal · 2025Article
- Polydrug use during chemsex: single and intersecting sexual effects of commonly used drugs.Frontiers in public health · 2025Review
- GHB, Chemsex and Chemical Submission: Investigating the Role of Sexuality on Victim Empathy and Blame Attribution in Drug-Facilitated Sexual Assault against Men.Behavioral sciences (Basel, Switzerland) · 2024Article
- Human laboratory models of reward in substance use disorder.Pharmacology, biochemistry, and behavior · 2024Review
- A Behavioral Economic Examination of Sexual Behaviors in the Era of Pre-exposure Prophylaxis via Explanatory Sequential Mixed Methods.Archives of sexual behavior · 2024Article
- Substance use and variation in sexual partnership rates among young MSM and young transgender women: Disaggregating between and within-person associations.Drug and alcohol dependence · 2023Article
- Delay Discounting and Sexual Decision-Making: Understanding Condom Use Behavior Among U.S. College Students.Archives of sexual behavior · 2023Article
- Risky Sexual Practices, Sexually Transmitted Infections, Motivations, and Mental Health among Heterosexual Women and Men Who Practice Sexualized Drug Use in Spain.International journal of environmental research and public health · 2022Article
- Methamphetamine administration dose effects on sexual desire, sexual decision making, and delay discounting.Experimental and clinical psychopharmacology · 2022Article
- Effects of substance use on monetary delay discounting among people who use stimulants with and without HIV: An ecological momentary assessment study.Experimental and clinical psychopharmacology · 2022Article
- Sexual behaviors, cannabis, alcohol and monkeypox infection.Frontiers in public health · 2022Review
- Poly-drug use among female and male commercial sex workers visiting a drop in centre in Mombasa County, Kenya.PLOS global public health · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesAlthough cocaine use has been linked to sexual HIV risk behavior for decades, the direct effects of cocaine on sexual desire and sexual decision-making are unexamined. Research suggests delay discounting (devaluation of future outcomes) and probability discounting (devaluation of uncertain outcomes) play roles in condom use decisions. This study examined the effect of cocaine administration on sexual desire, hypothetical condom use, and discounting tasks.
methodsThis double-blind, within-subjects study compared the effects of 0, 125, and 250 mg/70 kg oral cocaine HCl in 12 cocaine users. Measures included sexual desire and other subjective ratings, the Sexual Delay Discounting Task, the Sexual Probability Discounting Task, and monetary delay and probability discounting tasks.
resultsCocaine caused dose-related increases in sexual desire and prototypical stimulant abuse-liability ratings. Relative to placebo, cocaine did not significantly alter condom use likelihood when condoms were immediately available or when sex was associated with 100% certainty of sexually transmitted infection (STI). In contrast, cocaine dose-dependently strengthened the effect of delay (sexual delay discounting) and STI uncertainty (sexual probability discounting) in decreasing condom use likelihood. Cocaine caused no significant change in monetary delay and probability discounting.
conclusionThis is the first study showing that cocaine administration increases sexual desire. Detrimental effects of cocaine on sexual risk were only observed when safer sex required delay, or STI risk was uncertain (representative of many real-world scenarios), suggesting a critical role of discounting processes. Lack of monetary effects highlights the importance of studying clinically relevant outcomes when examining drug effects on behavioral processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.