ArticleNeurophotonics2017
Voltage-sensitive dye imaging of mouse neocortex during a whisker detection task.
Article in Neurophotonics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Fluorescent sensors for intracellular signaling in the brain: imaging neurons, glia, and vascular cells.Neurophotonics · 2025Article
- Dorsolateral Striatum is a Bottleneck for Responding to Task-Relevant Stimuli in a Learned Whisker Detection Task in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Global, Low-Amplitude Cortical State Predicts Response Outcomes in a Selective Detection Task in Mice.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Distributed and Localized Dynamics Emerge in the Mouse Neocortex during Reach-to-Grasp Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Modulation in cortical excitability disrupts information transfer in perceptual-level stimulus processing.NeuroImage · 2021Article
- Article
- In silico voltage-sensitive dye imaging reveals the emergent dynamics of cortical populations.Nature communications · 2021Article
- Characterizing Cortex-Wide Dynamics with Wide-Field Calcium Imaging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Article
- Neuromodulation of Brain State and Behavior.Annual review of neuroscience · 2020Review
- Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Projection-specific Activity of Layer 2/3 Neurons Imaged in Mouse Primary Somatosensory Barrel Cortex During a Whisker Detection Task.Function (Oxford, England) · 2020Article
- Sensorimotor processing in the rodent barrel cortex.Nature reviews. Neuroscience · 2019Review
- State-aware detection of sensory stimuli in the cortex of the awake mouse.PLoS computational biology · 2019Article
- Decoding cortical brain states from widefield calcium imaging data using visibility graph.Biomedical optics express · 2018Article
- Article
- The Cortical States of Wakefulness.Frontiers in systems neuroscience · 2018Review
- Long-Range, Border-Crossing, Horizontal Axon Radiations Are a Common Feature of Rat Neocortical Regions That Differ in Cytoarchitecture.Frontiers in neuroanatomy · 2018Article
- Catching the voltage gradient-asymmetric boost of cortical spread generates motion signals across visual cortex: a brief review with special thanks to Amiram Grinvald.Neurophotonics · 2017Review
- Imaging Cajal's neuronal avalanche: how wide-field optical imaging of the point-spread advanced the understanding of neocortical structure-function relationship.Neurophotonics · 2017Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensorimotor processing occurs in a highly distributed manner in the mammalian neocortex. The spatiotemporal dynamics of electrical activity in the dorsal mouse neocortex can be imaged using voltage-sensitive dyes (VSDs) with near-millisecond temporal resolution and [Formula: see text] spatial resolution. Here, we trained mice to lick a water reward spout after a 1-ms deflection of the C2 whisker, and we imaged cortical dynamics during task execution with VSD RH1691. Responses to whisker deflection were highly dynamic and spatially highly distributed, exhibiting high variability from trial to trial in amplitude and spatiotemporal dynamics. We differentiated trials based on licking and whisking behavior. Hit trials, in which the mouse licked after the whisker stimulus, were accompanied by overall greater depolarization compared to miss trials, with the strongest hit versus miss differences being found in frontal cortex. Prestimulus whisking decreased behavioral performance by increasing the fraction of miss trials, and these miss trials had attenuated cortical sensorimotor responses. Our data suggest that the spatiotemporal dynamics of depolarization in mouse sensorimotor cortex evoked by a single brief whisker deflection are subject to important behavioral modulation during the execution of a simple, learned, goal-directed sensorimotor transformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.