ArticleNeuroImage. Clinical2017
Resting-state theta band connectivity and graph analysis in generalized social anxiety disorder.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 89 citations in OpenAlex.
- Attentional Impairments and Neural Compensation in Adolescents with High Social Anxiety Traits: A Combined ERP and Functional Connectivity Study.Journal of Intelligence · 2026Article
- The general and specific in anxiety: an ERP study of social and spatial anxiety.Frontiers in human neuroscience · 2026Article
- The dual structure of anxiety: reconciling general and specific approaches.Frontiers in psychology · 2026Article
- Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents.Biological psychiatry global open science · 2025Article
- Rhythmic activity in resting-state EEG predicts trait anxiety.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Theta power reduction and theta-gamma coupling desynchronization are associated with working memory interference and anxiety symptoms in panic disorder: a retrospective study.BMC psychiatry · 2024Article
- Combined EEG-tDCS approach in resting state to reduce comorbid anxiety and depressive symptoms in affective disorders: A sham-controlled pilot study.IBRO neuroscience reports · 2024Article
- A systematic review of the biomarkers associated with cognition and mood state in bipolar disorder.International journal of bipolar disorders · 2024Article
- Alzheimer's disease diagnosis using rhythmic power changes and phase differences: a low-density EEG study.Frontiers in aging neuroscience · 2024Article
- Functional excitation-inhibition ratio for social anxiety analysis and severity assessment.Frontiers in psychiatry · 2024Article
- Prolonged Disease Course Leads to Impaired Brain Function in Anxiety Disorder: A Resting State EEG Study.Neuropsychiatric disease and treatment · 2024Article
- Neuroimaging Study of Brain Functional Differences in Generalized Anxiety Disorder and Depressive Disorder.Brain sciences · 2023Article
- Resting-state electroencephalographic characteristics related to mild cognitive impairments.Frontiers in psychiatry · 2023Article
- Neuromodulatory effects of transcranial electrical stimulation on emotion regulation in internalizing psychopathologies.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- Sex differences in amygdalohippocampal oscillations and neuronal activation in a rodent anxiety model and in response to infralimbic deep brain stimulation.Frontiers in behavioral neuroscience · 2023Article
- Machine learning for the detection of social anxiety disorder using effective connectivity and graph theory measures.Frontiers in psychiatry · 2023Article
- Transcranial alternating current stimulation for the treatment of major depressive disorder: from basic mechanisms toward clinical applications.Frontiers in human neuroscience · 2023Review
- Effects of Transcranial Direct Current Stimulation on Attentional Bias to Methamphetamine Cues and Its Association With EEG-Derived Functional Brain Network Topology.The international journal of neuropsychopharmacology · 2022Article
- Aberrated Multidimensional EEG Characteristics in Patients with Generalized Anxiety Disorder: A Machine-Learning Based Analysis Framework.Sensors (Basel, Switzerland) · 2022Article
- Association between resting-state EEG oscillation and psychometric properties in perimenopausal women.BMC women's health · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFunctional magnetic resonance imaging (fMRI) resting-state studies show generalized social anxiety disorder (gSAD) is associated with disturbances in networks involved in emotion regulation, emotion processing, and perceptual functions, suggesting a network framework is integral to elucidating the pathophysiology of gSAD. However, fMRI does not measure the fast dynamic interconnections of functional networks. Therefore, we examined whole-brain functional connectomics with electroencephalogram (EEG) during resting-state.
methodsResting-state EEG data was recorded for 32 patients with gSAD and 32 demographically-matched healthy controls (HC). Sensor-level connectivity analysis was applied on EEG data by using Weighted Phase Lag Index (WPLI) and graph analysis based on WPLI was used to determine clustering coefficient and characteristic path length to estimate local integration and global segregation of networks.
resultsWPLI results showed increased oscillatory midline coherence in the theta frequency band indicating higher connectivity in the gSAD relative to HC group during rest. Additionally, WPLI values positively correlated with state anxiety levels within the gSAD group but not the HC group. Our graph theory based connectomics analysis demonstrated increased clustering coefficient and decreased characteristic path length in theta-based whole brain functional organization in subjects with gSAD compared to HC.
conclusionsTheta-dependent interconnectivity was associated with state anxiety in gSAD and an increase in information processing efficiency in gSAD (compared to controls). Results may represent enhanced baseline self-focused attention, which is consistent with cognitive models of gSAD and fMRI studies implicating emotion dysregulation and disturbances in task negative networks (e.g., default mode network) in gSAD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.