ArticleClinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases
Rates and reasons for lack of persistence with anti-osteoporotic drugs: analysis of the Campania region database.
Article in Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 29 citations in OpenAlex.
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- Pharmacological Therapy of Osteoporosis: What's New?Clinical interventions in aging · 2020Review
- Geographical Variation in Medication Prescriptions: A Multiregional Drug-Utilization Study.Frontiers in pharmacology · 2020Article
- Drug Utilization Pattern of Antibiotics: The Role of Age, Sex and Municipalities in Determining Variation.Risk management and healthcare policy · 2020Article
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- Sirtuins and SIRT6 in Carcinogenesis and in Diet.International journal of molecular sciences · 2019Review
- Treatment Patterns of Diabetes in Italy: A Population-Based Study.Frontiers in pharmacology · 2019Article
- Fixed Versus Free Combinations Of Antihypertensive Drugs: Analyses Of Real-World Data Of Persistence With Therapy In Italy.Patient preference and adherence · 2019Article
- Persistence at 24 months with denosumab among postmenopausal women with osteoporosis: results of a prospective cohort study.Archives of osteoporosis · 2018Article
- Predictors of new oral anticoagulant drug initiation as opposed to warfarin in elderly adults: a retrospective observational study in Southern Italy.Therapeutics and clinical risk management · 2018Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subjects with chronic diseases are more likely to be nonpersistent to pharmacological treatment. Lack of persistence is common among subjects using oral anti-osteoporotic drugs, and leads to increased risk of fragility fracture. The aim of our retrospective study is to analyze the rates and reasons for discontinuation of anti-osteoporotic drugs in the Campania Region. Subjects aged over 40 years were included if they had received at least one prescription for any anti-osteoporotic drugs. Data were obtained from an administrative database of regional data on outpatient drug prescriptions reimbursed by the National Health Service. Patients were followed until the discontinuation of anti-osteoporotic therapy or until the end of the observation period. A total of 30,048 were incident users of anti-osteoporotic drugs: 28,317 (94.2%) females. The mean age of the cohort was 69.0±10.0 years. Weekly bis-phosphonates (51.1%) were the most commonly prescribed drugs. In the overall population, persistence rates were 34.8% after 6 months and 13.4% at one year. A multivariate Cox proportional hazard analysis showed that daily regimen (HR 1.9) treatments remained at higher risk of early discontinuation compared to weekly regimen therapies. Our data showed that the persistence to osteoporosis therapy is significantly worse than reported in literature.
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