ArticleThe EMBO journal1989
Evidence that introns arose at proto-splice sites.
Article in The EMBO journal, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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Who cites it
98 citing papers in PubMed, 244 citations in OpenAlex.
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- Intronization Signatures in Coding Exons Reveal the Evolutionary Fluidity of Eukaryotic Gene Architecture.Microorganisms · 2022Article
- The spread of the first introns in proto-eukaryotic paralogs.Communications biology · 2022Article
- Minor Intron Splicing from Basic Science to Disease.International journal of molecular sciences · 2021Review
- The Exon Junction Complex and intron removal prevent re-splicing of mRNA.PLoS genetics · 2021Article
- Review
- The evolution of hemocyanin genes in Tectipleura: a multitude of conserved introns in highly diverse gastropods.BMC ecology and evolution · 2021Article
- Comprehensive database and evolutionary dynamics of U12-type introns.Nucleic acids research · 2020Article
- Architecture and Distribution of Introns in Core Genes of FourG3 (Bethesda, Md.) · 2017Article
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- Recurrent loss of specific introns during angiosperm evolution.PLoS genetics · 2014Article
- Origin of spliceosomal introns and alternative splicing.Cold Spring Harbor perspectives in biology · 2014Article
- Trichinella pseudospiralis vs. T. spiralis thymidylate synthase gene structure and T. pseudospiralis thymidylate synthase retrogene sequence.Parasites & vectors · 2014Article
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- Gene make-up: rapid and massive intron gains after horizontal transfer of a bacterial α-amylase gene to Basidiomycetes.BMC evolutionary biology · 2013Article
- Advances in plant gene-targeted and functional markers: a review.Plant methods · 2013Article
- Identifying the mechanisms of intron gain: progress and trends.Biology direct · 2012Review
- Origin and evolution of spliceosomal introns.Biology direct · 2012Review
- In silico characterization of the neural alpha tubulin gene promoter of the sea urchin embryo Paracentrotus lividus by phylogenetic footprinting.Molecular biology reports · 2012Article
38 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The unexpected discovery of introns raised many questions about gene evolution. We provide evidence that actin and tubulin introns were gained between the G and R of the conserved coding sequence C/AAGR that is known to flank introns in general and which we call a proto-splice site. We conclude that the tubulin and actin introns are less ancient than the coding sequence and so could not have been involved in the primary evolution of the tubulin and actin genes.
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