ArticleFrontiers in pharmacology2016
Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABA
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In one paragraph
Article in Frontiers in pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 73 citations in OpenAlex.
- Exploring sex differences in endocannabinoid system biomarkers and their relationship with antidepressant treatment outcomes in major depressive disorder: a CAN-BIND 1 secondary analysis.European archives of psychiatry and clinical neuroscience · 2026Trial
- A Comparison of Positive and Negative Allosteric Modulators of α5-Containing GABABiological psychiatry · 2026Review
- Testosterone effect on anesthesia depth in micropenis hypospadias surgery: A prospective cohort study.Pakistan journal of medical sciences · 2026Article
- Negative allosteric modulation of α5-GABAbioRxiv : the preprint server for biology · 2026Article
- Dynamic Behavioral and Molecular Changes Induced by Chronic Restraint Stress Exposure in Mice.International journal of molecular sciences · 2025Article
- Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents.Biological psychiatry global open science · 2025Article
- Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- An alpha 5-GABAAutism research : official journal of the International Society for Autism Research · 2024Article
- Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses.bioRxiv : the preprint server for biology · 2024Article
- In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression.Communications biology · 2024Article
- Hormonal basis of sex differences in anesthetic sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Exploring the Therapeutic Potential of Gamma-Aminobutyric Acid in Stress and Depressive Disorders through the Gut-Brain Axis.Biomedicines · 2023Review
- Synthesis and Receptor Binding Studies of α5 GABAMolecules (Basel, Switzerland) · 2023Article
- Article
- Ablation ofGenes · 2023Article
- Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect.Frontiers in cellular neuroscience · 2023Article
- Effects of α5 GABACNS neuroscience & therapeutics · 2022Article
- Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice.Biological psychiatry · 2022Article
- Impact of stress on inhibitory neuronal circuits, our tribute to Bruce McEwen.Neurobiology of stress · 2022Article
- The role of spinal cord extrasynaptic αPhysiological reports · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Sean C PiantadosiCenter for Neuroscience, University of PittsburghPittsburgh, PA, USA; Department of Psychiatry, University of PittsburghPittsburgh, PA, USA.
Beverly J FrenchDepartment of Psychiatry, University of Pittsburgh Pittsburgh, PA, USA.
Michael M PoeDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee Milwaukee, WI, USA.
Tamara TimićDepartment of Pharmacology, University of Belgrade Belgrade, Serbia.
Bojan D MarkovićDepartment of Pharmaceutical Chemistry, University of Belgrade Belgrade, Serbia.
Mohan PabbaNeurobiology of Depression and Aging, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health Toronto, ON, Canada.
Marianne L SeneyDepartment of Psychiatry, University of Pittsburgh Pittsburgh, PA, USA.
Hyunjung OhCenter for Neuroscience, University of PittsburghPittsburgh, PA, USA; Department of Psychiatry, University of PittsburghPittsburgh, PA, USA; Neurobiology of Depression and Aging, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental HealthToronto, ON, Canada.
Beverley A OrserDepartment of Anesthesia-Department of Physiology, University of Toronto Toronto, ON, Canada.
Miroslav M SavićDepartment of Pharmacology, University of Belgrade Belgrade, Serbia.
James M CookDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee Milwaukee, WI, USA.
Etienne SibilleCenter for Neuroscience, University of PittsburghPittsburgh, PA, USA; Department of Psychiatry, University of PittsburghPittsburgh, PA, USA; Neurobiology of Depression and Aging, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental HealthToronto, ON, Canada; Department of Psychiatry- Department of Pharmacology and Toxicology, University of TorontoToronto, ON, Canada.
University of Pittsburgh · USUniversity of Belgrade · RSUniversity of Wisconsin–Milwaukee · USCentre for Addiction and Mental Health · CAUniversity of Toronto · CA
Funding
Molecular Aging of the Human Brain: Genetic Modulation and Functional OutcomesR01MH093723 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SIBILLE, ETIENNE L · 2011 to 2015
$2.6MDevelopment of new drugs for asthma by targeting GABA(A) receptors in the lungR01HL118561 · NHLBI · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2014 to 2017
$2.0MDesign of New Therapeutic Agents to Treat SchizophreniaR01MH096463 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2013 to 2017
$1.9MSynthesis of Alpha2/Alpha3 GABA Agonists to Treat Neuropathic PainR01NS076517 · NINDS · UNIVERSITY OF WISCONSIN MILWAUKEE · PI COOK, JAMES M · 2012 to 2015
$1.3MNHLBI NIH HHS R01 HL118561NIMH NIH HHS R01 MH093723NIMH NIH HHS R01 MH096463NINDS NIH HHS R01 NS076517
Abstract
PubMed holds no abstract for this paper.
Indexed as
alpha5depressionGABAGabra5interneuronsPAM
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.