ArticleCase reports in gastroenterology
Neurofibroma of the Colon: A Diagnostic Mimicker of Gastrointestinal Stromal Tumor.
Article in Case reports in gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- An Isolated Colonic Neurofibroma Without Systemic Neurofibromatosis: A Rare Case Report and Literature Review.The American journal of case reports · 2026Review
- A Comparative Analysis of GISTs and Schwannomas in the Sigmoid Colon: Case Report and Review of the Management Strategies.Journal of clinical medicine · 2025Review
- Article
- MULTIPLE NEUROENDOCRINE NEOPLASIA IN A PATIENT WITH TYPE I NEUROFIBROMATOSIS (NF1): REPORT OF A NEW MUTATION (NF1, EXONS 2-30 DELETION) AND LITERATURE REVIEW.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2023Review
- Sporadic Neurofibroma of the Peritoneal Cavity.ACG case reports journal · 2022Article
- Plexiform fibromyxoma: Review of rare mesenchymal gastric neoplasm and its differential diagnosis.World journal of gastrointestinal oncology · 2021Review
- Isolated colonic neurofibroma, a rare tumor: A case report and review of literature.World journal of clinical cases · 2020Article
- Isolated colonic neurofibroma in the setting of Lynch syndrome: A case report and review of literature.World journal of gastrointestinal surgery · 2020Article
- Sporadic neurofibroma of transverse colon in a patient without neurofibromatosis type 1: A case report.International journal of surgery case reports · 2020Article
- When a polyp is not a polyp: incidental finding of a sigmoid schwannoma at first colonoscopic screening.BMJ case reports · 2018Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastrointestinal neurofibroma usually develops as diffuse gastrointestinal involvement in neurofibromatosis type 1 patients. Only 4 cases of sporadic colonic neurofibroma in a patient without neurofibromatosis type 1 have been reported in the English literature. A 26-year-old female patient underwent colonoscopy, and a 4-cm-sized polypoid mass was identified in the sigmoid colon. Wedge resection of the mass showed a yellowish, hard submucosal tumor. Microscopically, the tumor was composed of wavy spindle cells, fibroblasts, and strands of collagen; the stroma showed scattered myxoid areas. The differential diagnoses included gastrointestinal stromal tumor, schwannoma, and neurofibroma. Immunohistochemistry for c-Kit, DOG (discovered on gastrointestinal stromal tumors)-1, smooth muscle actin, S-100 protein, and CD34 was performed. The tumor cells were diffusely positive for CD34 and S-100 protein, while they were completely negative for c-Kit, DOG-1, and smooth muscle actin. The final diagnosis was neurofibroma. Sporadic colonic neurofibroma is very rare. Given the diffuse positivity for CD34 and its rarity, colonic neurofibroma can be easily misdiagnosed as gastrointestinal stromal tumor. Recognition of this entity would be beneficial for pathologists to avoid misdiagnosis and unnecessary treatment.
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